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Human Type II Alveolar Epithelial Cells

  • BSL
  • 600
Human Type-II Pulmonary Alveolar Epithelial Cells (HPAEpiC-II) provided by AcceGen have been isolated from human normal lung tissue. HPAEpiC-II are cryopreserved as primary cultures and shipped with dry ice. AcceGen also offers optimized media and reagents for the growth and in vitro maintenance of Human Type-II Pulmonary Alveolar Epithelial Cells which are quality tested together […]
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Home | Primary Cells | Human Primary Cells | Respiratory System Primary Cells | Human Type II Alveolar Epithelial Cells

Introduction to Type II Alveolar Cells
Human Type II Alveolar Epithelial Cells (PAEpiC2), also known as Type 2 Pneumocytes or AT2 Cells, are isolated from human lung tissue, playing a critical role in retaining the alveoli integrity and function. The Alveolar Type II Cells are specialized to produce surfactant, which reduces surface tension in the alveoli. ACE2 cells function in the repair process after lung injury by proliferating and spreading to cover the alveolar surface.

Applications of Type II Alveolar Cells
Study the pathogenic mechanism of lung disease samples from the cellular and molecular levels through the collection and identification of surface-active proteins.
The Type II Pneumocytes injury is found in some typical severe lung diseases, such as idiopathic pulmonary fibrosis. Study has proven that COVID-19 would affect alveolar epithelial cells. Therefore, AT2 Epithelial Cells is a good choice for COVID-19 research. Human Alveolar Type 2 cells are considered to have the potential to replace cell lines to study the repair mechanism.

Why Choose AT2 Cells from AcceGen?
Cells are derived from normal lung tissue with high purity.
Cells are negative in HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi.
Pulmonary surfactant protein A (SP-A) was positive by immunofluorescence staining.
Cryopreserved Human Pulmonary Alveolar Epithelial Cells are also available at AcceGen.

Species

Human
Cat.No

ABC-TC5515
Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Epithelial
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Lung
Disease

Normal
Storage

Liquid Nitrogen
Product Type

Pulmonary Cells

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Yoshihiro Nakata, Hirotaka Ode, Mai Kubota, Takaaki Kasahara, Kazuhiro Matsuoka, Atsuko Sugimoto, Mayumi Imahashi, Yoshiyuki Yokomaku, Yasumasa Iwatani, Cellular APOBEC3A deaminase drives mutations in the SARS-CoV-2 genome, Nucleic Acids Research, Volume 51, Issue 2, 25 January 2023, Pages 783–795, https://doi.org/10.1093/nar/gkac1238.

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AT2 Cells

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Application

  • For research use only

Frequently Asked Questions

  • What are Human Type II Alveolar Epithelial Cells?

    Human Type II Alveolar Epithelial Cells (AEC II) are specialized cells located in the alveoli of the lungs. They are responsible for the production and secretion of surfactant, a substance that reduces surface tension within the alveoli, preventing lung collapse. Additionally, they play a role in alveolar repair and regeneration.

  • What are the primary functions of Type II Alveolar Epithelial Cells?

    The primary functions of Type II Alveolar Epithelial Cells include:
    – Producing and secreting pulmonary surfactant to lower surface tension in the alveoli.
    – Acting as progenitor cells for the alveolar epithelium, allowing for repair and regeneration of the lung tissue.
    – Participating in the immune defense of the lungs by engulfing and processing foreign particles.

  • What are the applications of Human Type II Alveolar Epithelial Cells in research?

    Human Type II Alveolar Epithelial Cells are used in a variety of research applications, including:
    – Studying lung physiology and pathology.
    – Investigating mechanisms of lung diseases such as acute respiratory distress syndrome (ARDS), pulmonary fibrosis, and chronic obstructive pulmonary disease (COPD).
    – Developing and testing new drugs and therapies for lung conditions.
    – Exploring cell-based therapies for lung regeneration and repair.

  • Do Type II Alveolar Epithelial Cells transdifferentiate into other cell types?

    Yes, Type II Alveolar Epithelial Cells have the capacity to transdifferentiate into Type I Alveolar Epithelial Cells. Type I cells cover a large surface area of the alveolar walls and are involved in gas exchange. This transdifferentiation is crucial for the repair and regeneration of the alveolar epithelium following lung injury.

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Tags

  • Endothelial (424)
  • Human (1729)
  • Normal (1578)
  • Pulmonary (23)

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