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Human Type II Alveolar Epithelial Cells

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Product Name

Human Type II Alveolar Epithelial Cells

Price Get Quote
Cat.No

ABC-TC5515

Species

Human

Size/Quantity

1 vial

Shipping Info

Dry Ice

Storage

Liquid Nitrogen

Description

Introduction to Type II Alveolar Cells
Human Type II Alveolar Epithelial Cells (PAEpiC2), also known as Type 2 Pneumocytes or AT2 Cells, are isolated from human lung tissue, playing a critical role in retaining the alveoli integrity and function. The Alveolar Type II Cells are specialized to produce surfactant, which reduces surface tension in the alveoli. ACE2 cells function in the repair process after lung injury by proliferating and spreading to cover the alveolar surface.

Applications of Type II Alveolar Cells
Study the pathogenic mechanism of lung disease samples from the cellular and molecular levels through the collection and identification of surface-active proteins.
The Type II Pneumocytes injury is found in some typical severe lung diseases, such as idiopathic pulmonary fibrosis. Study has proven that COVID-19 would affect alveolar epithelial cells. Therefore, AT2 Epithelial Cells is a good choice for COVID-19 research. Human Alveolar Type 2 cells are considered to have the potential to replace cell lines to study the repair mechanism.

Why Choose AT2 Cells from AcceGen?
Cells are derived from normal lung tissue with high purity.
Cells are negative in HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi.
Pulmonary surfactant protein A (SP-A) was positive by immunofluorescence staining.
Cryopreserved Human Pulmonary Alveolar Epithelial Cells are also available at AcceGen.

Disease

Normal

Source Organ

Lung

Recommended Medium And Supplement

ABM-TM5515 Human Type II Alveolar Epithelial Cells Medium Kit

Citation Guide

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Yoshihiro Nakata, Hirotaka Ode, Mai Kubota, Takaaki Kasahara, Kazuhiro Matsuoka, Atsuko Sugimoto, Mayumi Imahashi, Yoshiyuki Yokomaku, Yasumasa Iwatani, Cellular APOBEC3A deaminase drives mutations in the SARS-CoV-2 genome, Nucleic Acids Research, Volume 51, Issue 2, 25 January 2023, Pages 783–795, https://doi.org/10.1093/nar/gkac1238.

Application

For research use only

Key Features

-Backed by AcceGen advanced technology
-Cryopreserved for highest viability and plating efficiency
-Quality-tested for accurate results

Growth Conditions

37 ℃, 5% CO2

Cell Type

Epithelial

Growth Mode

Adherent

Product Type

Pulmonary Cells

Product Image

AT2 Cells

Frequently Asked Questions

  • What are Human Type II Alveolar Epithelial Cells?

    Human Type II Alveolar Epithelial Cells (AEC II) are specialized cells located in the alveoli of the lungs. They are responsible for the production and secretion of surfactant, a substance that reduces surface tension within the alveoli, preventing lung collapse. Additionally, they play a role in alveolar repair and regeneration.

  • What are the primary functions of Type II Alveolar Epithelial Cells?

    The primary functions of Type II Alveolar Epithelial Cells include:
    – Producing and secreting pulmonary surfactant to lower surface tension in the alveoli.
    – Acting as progenitor cells for the alveolar epithelium, allowing for repair and regeneration of the lung tissue.
    – Participating in the immune defense of the lungs by engulfing and processing foreign particles.

  • What are the applications of Human Type II Alveolar Epithelial Cells in research?

    Human Type II Alveolar Epithelial Cells are used in a variety of research applications, including:
    – Studying lung physiology and pathology.
    – Investigating mechanisms of lung diseases such as acute respiratory distress syndrome (ARDS), pulmonary fibrosis, and chronic obstructive pulmonary disease (COPD).
    – Developing and testing new drugs and therapies for lung conditions.
    – Exploring cell-based therapies for lung regeneration and repair.

  • Do Type II Alveolar Epithelial Cells transdifferentiate into other cell types?

    Yes, Type II Alveolar Epithelial Cells have the capacity to transdifferentiate into Type I Alveolar Epithelial Cells. Type I cells cover a large surface area of the alveolar walls and are involved in gas exchange. This transdifferentiation is crucial for the repair and regeneration of the alveolar epithelium following lung injury.

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Reviews of Human Type II Alveolar Epithelial Cells
AcceGen is always trying to do right by our customers and working hard to build a higher quality product.

2 thoughts on “Human Type II Alveolar Epithelial Cells”


Date: 08-27-2020 04:31:54


Purchased two vials AECII for research on COVID19 virus, we received the cells in dry ice with detailed culture instruction, our technical person are working on culturing the cells and the instruction helps a lot.


Quote No.: AGS6802 Name: Omar Khan


Date: 10-27-2022 12:15:20


We received two products. One is Human Type II Alveolar Epithelial cells Medium kit. Another is Human Type II Alveolar Epithelial. To obtain quote and place order is very convience.


Quote No.: AGK2582-1 Name: Shanzhong Yang

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