Thymic epithelial cells (TyEpiC) are major component of thymic stroma with a high degree of phenotypical and functional heterogeneity. They can be broadly categorized into cortical and medullary thymic epithelial cells. Primary thymic epithelial cells are indispensable to the thymopoeisis and stepwise development of T cells. Immature thymocytes are selected by the MHC complexes presented on thymic epithelial cell surface and become self-tolerant and functionally competent T cells. Dysfunction of thymic epithelial cells is often associated with autoimmune disease and immunodeficiency.
Why choose Human Thymic Epithelial Cells from AcceGen?
AcceGen Human thymic epithelial cells are isolated from healthy human thymus. Cells at passage 3 are cryopreserved to ensure best viability. Each vial contains more than 5×10^5 cells in 1ml volume. Human thymic epithelial cells are tested for expression of E-cadherin or ZO-1 using immunofluorescence. All cell lots are tested negative for HIV-1, HBV, HCV, mycoplasma, yeast, fungi and other pathogens. Human thymic epithelial cells are guaranteed for further expansion following protocols provided by AcceGen. Human thymic epithelial cells have limited expansion capacity and as a result are not recommended for long-term culturing.
