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Human Thymic Epithelial Cells | ||||
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| Product Name | Human Thymic Epithelial Cells | |||
| Price | Get Quote | |||
| Cat.No | ABC-TC5517 | Species | Human | |
| Size/Quantity | 1 vial | |||
| Shipping Info | Dry Ice | Storage | Liquid Nitrogen | |
| Description | Thymic epithelial cells (TyEpiC) are major component of thymic stroma with a high degree of phenotypical and functional heterogeneity. They can be broadly categorized into cortical and medullary thymic epithelial cells. Primary thymic epithelial cells are indispensable to the thymopoeisis and stepwise development of T cells. Immature thymocytes are selected by the MHC complexes presented on thymic epithelial cell surface and become self-tolerant and functionally competent T cells. Dysfunction of thymic epithelial cells is often associated with autoimmune disease and immunodeficiency. Why choose Human Thymic Epithelial Cells from AcceGen? AcceGen Human thymic epithelial cells are isolated from healthy human thymus. Cells at passage 3 are cryopreserved to ensure best viability. Each vial contains more than 5×10^5 cells in 1ml volume. Human thymic epithelial cells are tested for expression of E-cadherin or ZO-1 using immunofluorescence. All cell lots are tested negative for HIV-1, HBV, HCV, mycoplasma, yeast, fungi and other pathogens. Human thymic epithelial cells are guaranteed for further expansion following protocols provided by AcceGen. Human thymic epithelial cells have limited expansion capacity and as a result are not recommended for long-term culturing. | |||
| Disease | Normal | |||
| Source Organ | Thymus | |||
| Recommended Medium And Supplement | ABM-TM5517 Human Thymic Epithelial Cells Medium Kit | |||
| Citation Guide | When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID). | |||
| Application | For research use only Due to their importance in orchestrating immune system, thymic epithelial cells have become attractive target for cell therapies and can have wide application in research and clinical settings, including: -Identification and characterization of sub-populations. -Interaction with various transcription factors, such as autoimmune regulator AIRE, and the impact on thymic microenvironment. -Expression of peripheral antigens on thymic epithelial cells that facilitate positive and negative selection of T cells. -Autoimmune and inflammatory diseases associated with thymic epithelial cell dysfunction. -Cytokines, chemokines, costimulatory molecules, and transcription factors expression of thymic epithelial cells under various stimulations. -Other research considering thymic epithelial cells function, developmental progress, and reconstitution after surgery. | |||
| Key Features | -Backed by AcceGen advanced technology -Cryopreserved for highest viability and plating efficiency -Quality-tested for accurate results -Expert teams to provide timely support and assist best experimental outcomes | |||
| Growth Conditions | 37 ℃, 5% CO2 | |||
| Cell Type | Epithelial | |||
| Growth Mode | Adherent | |||
| Product Type | Immune Cells | |||
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