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Human Splenic Fibroblasts

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Fibroblasts are mesenchymal cells derived from the embryonic mesoderm. They have been extensively used for a wide range of cellular and molecular studies. This is mainly because they are one of easiest types of cells to grow in culture, and their durability makes them amenable to a wide variety of manipulations ranging from studies employing […]
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Home | Primary Cells | Human Primary Cells | Immune System Primary Cells | Human Splenic Fibroblasts

Human splenic fibroblasts are derived from the largest secondary lymphoid organ in the body, the spleen, which plays a crucial role in immune defense. These fibroblastic cells are best studied in the splenic white pulp and can be classified into three subsets: T-zone reticular cells (TRC) expressing CCL21, follicular dendritic cells (FDC) expressing CXCL13 and CR1/2, and marginal reticular cells (MRC) expressing CXCL13, MAdCAM1, and RANKL. In the recent study, human spleen fibroblasts exhibit heterogeneity, including Bst1+ white pulp fibroblasts, Ly6c1+ red pulp fibroblasts, Mcam+ pericytes/vascular smooth muscle cells (VSMC), and Cd34+ adventitial cells, etc.

 

Why choose Human Splenic Fibroblasts from AcceGen?

Human Splenic Fibroblasts are characterized by their lack of von Willebrand Factor/Factor VIII, cytokeratin 18, and alpha-smooth muscle actin expression. They are thoroughly tested negative of contamination from bacterial, yeast, fungal, and mycoplasma. Additionally, they have the capacity to undergo further expansion for 15 population doublings under specific conditions. With these features, Human Splenic Fibroblasts serve as reliable and versatile tools for spleen-related research and related disciplines.

Product Code

HSF
Species

Human
Cat.No

ABC-TC3818
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Fibroblast
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Spleen
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Spleen Cells

Citation

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Application

  • FOR RESEARCH USE ONLY

  • Human splenic fibroblasts have diverse applications. They help determine receptors and markers involved in proliferation, tissue repair, and inflammation. They are useful in establishing in vitro disease models for high throughput and high content screening, allowing researchers to study disease conditions and test potential interventions. Additionally, studying the role of spleen fibroblasts in the spleen’s structure and their regulation of neighboring cell types provides insights into immune functions and host defense mechanisms. This knowledge can contribute to the development of targeted therapies and advancements in immune-related treatments.

Frequently Asked Questions

  • What is the primary function of Human Splenic Fibroblasts in the spleen's architecture?

    These fibroblasts provide structural support to the spleen and maintain the integrity of splenic tissue.

  • Can Human Splenic Fibroblasts be used for studying fibrosis in splenic diseases?

    Yes, they are suitable for investigating the role of fibroblasts in splenic fibrosis and related pathologies.

  • What are the typical culture conditions for Human Splenic Fibroblasts?

    They should be cultured in a fibroblast-specific medium, supplemented with essential growth factors.

  • How do Human Splenic Fibroblasts interact with immune cells in the spleen?

    These cells play a role in modulating immune responses by interacting with various immune cell types.

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Tags

  • Fibroblast (273)
  • Human (1729)
  • Normal (1578)
  • Spleen (35)

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