Spleen plays an important role in fighting blood born disease and filtering blood where pathogens, cellular debris and damaged and effete red blood cells are removed. Human splenic endothelial cells (HSEC) are one of the key components of the red pulp of the spleen. The endothelial cells loosely line the venous sinuses. They are connected by the stress fibers and arranged in parallel, which forms spleen specific interendothelial slits (IES) that forces blood to move from cords into the sinuses. The slit selectively allows passage of healthy red blood cells while aging red blood cells with stiffening membranes are filtered for phagocytosis.
Why choose Human Splenic Endothelial Cells from AcceGen?
AcceGen human splenic endothelial cells are isolated from fully consented healthy human spleen. HSEC cells at passage 1 are cryopreserved to ensure best viability. Each vial contains more than 5×10^5 cells. All cell lots are tested negative for HIV-1, HBV, HCV, mycoplasma, yeast, fungi and other pathogens. Human splenic endothelial cells are guaranteed for further expansion of at least 12 population doublings using AcceGen recommended cell culture media.
