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Human Splenic Endothelial Cells | ||||
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| Product Name | Human Splenic Endothelial Cells | |||
| Price | Get Quote | |||
| Product Code | HSEC | |||
| Cat.No | ABC-TC3817 | Species | Human | |
| Size/Quantity | 1 vial | Biosafety Level | 1 | |
| Shipping Info | Dry Ice | Storage | Liquid Nitrogen | |
| Description | Spleen plays an important role in fighting blood born disease and filtering blood where pathogens, cellular debris and damaged and effete red blood cells are removed. Human splenic endothelial cells (HSEC) are one of the key components of the red pulp of the spleen. The endothelial cells loosely line the venous sinuses. They are connected by the stress fibers and arranged in parallel, which forms spleen specific interendothelial slits (IES) that forces blood to move from cords into the sinuses. The slit selectively allows passage of healthy red blood cells while aging red blood cells with stiffening membranes are filtered for phagocytosis. Why choose Human Splenic Endothelial Cells from AcceGen? AcceGen human splenic endothelial cells are isolated from fully consented healthy human spleen. HSEC cells at passage 1 are cryopreserved to ensure best viability. Each vial contains more than 5×10^5 cells. All cell lots are tested negative for HIV-1, HBV, HCV, mycoplasma, yeast, fungi and other pathogens. Human splenic endothelial cells are guaranteed for further expansion of at least 12 population doublings using AcceGen recommended cell culture media. | |||
| Disease | Normal | |||
| Source Organ | Spleen | |||
| Quality Control | All cells test negative for mycoplasma, bacteria, yeast, and fungi. | |||
| Recommended Medium And Supplement | ABM-TM3817 Human Splenic Endothelial Cells Medium Kit | |||
| Citation Guide | When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID). | |||
| Application | For research use only Human spleen endothelial cells are similar to other endothelial cells where they maintain blood fluidity and regulate blood-tissue barrier. Splenic endothelial cells also have supportive role on the growth of dendritic cell in vitro and can be used to study endothelial cell-macrophage interaction. They are also useful tool for study myelofibrosis where the genetic profiling has revealed certain mutations of spleen endothelial cells are associated with the disease. | |||
| Key Features | -Backed by AcceGen advanced technology -Cryopreserved for highest viability and plating efficiency -Quality-tested for accurate results -Expert teams to provide timely support and assist best experimental outcomes | |||
| Growth Conditions | 37 ℃, 5% CO2 | |||
| Cell Type | Endothelial | |||
| Product Type | Spleen Cells | |||
| Product Image |  | |||
Frequently Asked Questions
What role do Human Splenic Endothelial Cells play in immune system function?
These cells are essential for regulating immune responses by filtering blood and interacting with lymphocytes.
Are Human Splenic Endothelial Cells involved in the clearance of aged or damaged red blood cells?
Yes, these cells play a critical role in the removal of old or damaged red blood cells from circulation.
Can Human Splenic Endothelial Cells be used to study vascular diseases specific to the spleen?
Yes, they are suitable for researching splenic vascular disorders and immune-related conditions.
How do Human Splenic Endothelial Cells contribute to the spleen's filtration of pathogens?
These cells help trap and clear pathogens from the bloodstream, supporting the spleen’s immune functions.
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