The human retina is a multi-layered structure lining the rear of the eye. It consists of photoreceptor cells and retinal pigment epithelial cells (RPE). RPE situated between the neurosensory retina and the choroid, form the outer blood-retina barrier that controls the chemical composition of the subretinal space. RPE has long been recognized to differ from […]
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All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category
Primary Cells
Size/Quantity
1 vial
Cell Type
Epithelial
Shipping Info
Dry Ice
Growth Conditions
37 ℃, 5% CO2
Source Organ
Retina
Disease
Normal
Biosafety Level
1
Storage
Liquid Nitrogen
Product Type
Ocular Cells
Description
Human retinal pigment epithelial (HRPE) cells are isolated from human retinal pigment tissue with the digestion by collagenase. They are a single layer of densely packed regular polygonal cells, filled with pigment granules, and positioned at the outermost layer of the retina. Within the HRPE cells, microvillous structures extend between photoreceptor outer segments (POS), contributing to the HRPE’s phagocytic function. The integrity and functionality of the HRPE are crucial, as any impairment can give rise to a range of retinopathies, for which effective treatments are currently lacking. Moreover, damage to RPE cells is closely associated with numerous retinal degenerative conditions, including age-related macular degeneration, retinitis pigmentosa, and Stargardt’s disease.
Why choose Human Retinal Pigment Epithelial Cells from AcceGen?
AcceGen’s Human retinal pigment epithelial (HRPE) cells offer several advantages. They are cryopreserved at passage one and guaranteed to expand for 10 population doublings. AcceGen also provides optimized medium and reagents, ensuring maximum performance for in vitro HRPE cell culture. This comprehensive solution offers researchers a reliable and efficient system for studying the development, function, and pathobiology of the retinal pigment epithelium. With AcceGen’s HRPE cells, researchers can confidently conduct their studies, benefiting from the high-quality cells and optimized culture conditions provided by a trusted supplier.
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Citation
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Application
FOR RESEARCH USE ONLY
Understanding the normal function of HRPE cells and their role in retinal diseases is crucial for preventing and treating retinopathies. The HRPE is a vital layer of cells between the retina and choroid, responsible for maintaining retinal health and performing essential functions. By studying HRPE cells, we gain insights into the development, function, and pathobiology of the HRPE, enabling us to address conditions such as age-related macular degeneration, retinitis pigmentosa, diabetic retinopathy, photoreceptor degeneration, gene expression, and cellular interactions. These investigations provide valuable knowledge for improving diagnosis, understanding disease mechanisms, and developing effective therapeutic interventions.
Frequently Asked Questions
What are Human Retinal Pigment Epithelial Cells?
Human Retinal Pigment Epithelial (RPE) Cells are specialized pigmented cells located in the outermost layer of the retina. They provide essential support to photoreceptors, facilitate nutrient transport, and play a crucial role in visual function by absorbing stray light and maintaining retinal health.
What is the impact of dysfunction or degradation of Human Retinal Pigment Epithelial Cells?
Dysfunction or degeneration of RPE cells is associated with several retinal diseases, including age-related macular degeneration (AMD) and retinitis pigmentosa. Loss of RPE cell function can lead to photoreceptor death, resulting in vision loss.
What are Human Retinal Pigment Epithelial Cells used for in research?
These cells are extensively used in research focused on retinal diseases, photoreceptor biology, drug discovery, and tissue engineering. They are also integral to studies investigating the pathophysiology of AMD and the development of cell-based therapies for retinal degeneration.
Can Human Retinal Pigment Epithelial Cells be used in regenerative medicine?
Yes, RPE cells are widely researched for use in regenerative therapies, especially for treating diseases like AMD. Transplantation of healthy RPE cells into the retina holds promise for restoring function in damaged retinal tissues and preventing further vision loss.
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for which effective treatments are currently lacking. Moreover, damage to RPE cells is closely associated with numerous retinal degenerative conditions, including age-related macular degeneration, retinitis pigmentosa, and Stargardt’s disease.
