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Human Retinal Muller Cells | ||||
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| Product Name | Human Retinal Muller Cells | |||
| Price | Get Quote | |||
| Cat.No | ABC-TC133L | Species | Human | |
| Cell Type | Muller Cell | |||
| Growth Mode | Adherent | |||
| Size/Quantity | 1 vial | Biosafety Level | 1 | |
| Shipping Info | Dry Ice | Storage | Liquid Nitrogen | |
| Description | Müller cells (MCs) (retinal gliocytes, Müller glia) are the most common of the 3 glial cells found in the human retina, followed by astroglia and microglia. MCs have been shown to originate from neural crest cells. MCs cover the entire thickness of the retina and have interactions with every type of neuronal cell body. They form architectural support structures stretching radially across the thickness of the retina and are the limits of the retina at the outer and inner limiting membrane, respectively. Muller cells contain glycogen, mitochondria, and intermediate filaments that are immunoreactive for vimentin and to some extent to glial fibrillary acidic protein (GFAP).
Why choose Human Retinal Muller Cells from AcceGen? These cells are freshly isolated and cryopreserved at early passage, ensuring excellent viability and consistent morphology when revived. With rigorous quality control protocols, AcceGen guarantees that each batch is mycoplasma-free, delivering pure and reliable cells for research, making them ideal for producing accurate and reproducible experimental outcomes. | |||
| Disease | Normal | |||
| Source Organ | Retina | |||
| Quality Control | All cells test negative for mycoplasma, bacteria, yeast, and fungi. | |||
| Recommended Medium And Supplement | ABM-TM133L Human Retinal Muller Medium Kit | |||
| Citation Guide | When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID). | |||
| Application | FOR RESEARCH USE ONLY Human Retinal Müller Cells are tools for studying the human retina and understanding retinal diseases. Müller cells play a critical role in retinal health, and their vulnerability is closely linked to photoreceptor cell pathology, particularly during aging. These cells are useful for research into the various, yet not fully understood, roles they play in retinal diseases. Investigating Müller cell functions and dysfunctions can provide insights into retinal disease mechanisms. Additionally, their ability to dedifferentiate into progenitor-like cells holds promise for future therapeutic approaches. A deeper understanding of the gliotic mechanisms underlying reactive Müller cells can aid in developing strategies that enhance their protective and regenerative properties while reducing their toxicity, potentially leading to more effective treatments for retinal disorders. | |||
| Growth Conditions | 37 ℃, 5% CO2 | |||
| Product Type | Ocular Cells | |||
| Product Image |  | |||
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Frequently Asked Questions
What are Human Retinal Muller Cells and what is their primary function?
Human Retinal Muller Cells are a type of mammalian retinal glial cell that play a crucial role in supporting the structural integrity of the retina. They provide structural support to the retinal cells and are involved in various pathological processes such as glaucoma and diabetic retinopathy.
How many cells are contained in each vial of Human Retinal Muller Cells?
Each vial of Human Retinal Muller Cells contains at least 5×10^5 cells. This quantity ensures that researchers have a sufficient number of cells for various experimental applications, such as studying retinal structure and function, investigating disease mechanisms, and testing potential treatments. The high cell count per vial facilitates multiple assays or experiments, enhancing the efficiency and reliability of research outcomes.
What role do Muller cells play in retinal enviroment?
Muller cells play a crucial role in maintaining and repairing the retinal environment. They respond to retinal injury and disease, contributing to the pathological processes of conditions such as glaucoma and diabetic retinopathy. By reacting to damage and supporting the retinal structure, they influence the progression and response to these diseases.
Why are Human Retinal Muller Cells useful for research?
Human Retinal Muller Cells are useful for research because they are integral to understanding the cellular and molecular mechanisms underlying retinal health and disease. Studying these cells can provide insights into the development and progression of retinal diseases and aid in the development of new therapeutic strategies.
What are the typical research applications of Human Retinal Muller Cells?
Typical research applications of Human Retinal Muller Cells include studies on retinal structure and function, investigations into the mechanisms of retinal diseases such as glaucoma and diabetic retinopathy, and the development and testing of new treatments for these conditions. They are also used in studies exploring the general physiology and pathology of the retinal environment.
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