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Human Astrocytes-Retina

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Astrocytes make up the majority of the cells in the mammalian brain. They are the most variable in type, most intimately associated with all parts of neurons, and thus most functionally interesting in their relationships with neurons. They provide structural, trophic, and metabolic support to neurons and modulate synaptic activity. Impairment of these astrocyte functions […]
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Home | Primary Cells | Human Primary Cells | Nervous System Primary Cells | Human Astrocytes-Retina

Retinal astrocytes are a type of glial cells that are located in the retinal nerve fiber and ganglion cell layers and provides them with intrinsic protection and support. In human retina, there are two types of astrocytes can be distinguished, that is elongated astrocytes and star-shaped astrocytes. Both astrocytes are variants or subclasses of a single type of astrocyte, specializing in different ways. Star-shaped astrocytes specialize more in relations with the blood vessels and elongated astrocytes with the axons. The recent studies show that transcription factor Pax8 can be as a highly specific marker of retinal astrocytes.

 

Why choose Human Retinal Astrocytes from AcceGen?

Human Retinal Astrocytes (HRA) from AcceGen are isolated from human retina and cryopreserved at early passage. HRA are cryopreserved in a cryogenic vial, providing a convenient storage format and are guaranteed to further expand for 15 population doublings under the conditions provided. The cell density per tube is more than 5×105/ml. HRA are negative for mycoplasma.

Product Code

HRA
Species

Human
Cat.No

ABC-TC3787
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Astrocyte
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Retina
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Ocular Cells

Citation

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AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • FOR THE RESEARCH USE ONLY

  • Retinal astrocytes are responsible for the maintenance of the retinal microenvironment and structural support. They are involved in retinal glucose metabolism, providing retinal neurons with the necessary nutrients for oxidative metabolism. They are also involved in regulating proper immune responses. In retinopathy, astrocytes adopt defensive programs, which is disease- and context-specific and involves the activation of thousands of genes to maintain retinal homeostasis.

  • Studies have shown that astrocytes can trigger the inflammation in glaucoma. Under glaucoma, they become reactive and change their phenotypes into neurotoxic ones. They release neurotoxic factors such as cytokines and chemokines and damage axons of retinal ganglion cells.

Frequently Asked Questions

  • What are Human Retinal Astrocytes?

    Human Retinal Astrocytes are glial cells found in the retina, where they provide structural and functional support to neurons and blood vessels. They play a key role in maintaining retinal homeostasis, regulating the blood-retinal barrier, and responding to injury or disease.

  • What role do Human Retinal Astrocytes play in response to retinal injury?

    When the retina is damaged, retinal astrocytes become reactive, proliferating and releasing signaling molecules that mediate inflammation and repair. This process, known as gliosis, can either support regeneration or contribute to scarring depending on the extent of injury.

  • Can Human Retinal Astrocytes be used to model retinal diseases?

    Yes, Human Retinal Astrocytes are valuable in modeling retinal diseases, particularly those involving neurodegeneration and vascular dysfunction. They are used to study conditions such as glaucoma, age-related macular degeneration, and retinal ischemia.

  • What are the typical culture conditions for Human Retinal Astrocytes?

    These cells are cultured in a specialized medium enriched with factors that support astrocyte growth and function, such as neurotrophic factors. They thrive in environments at 37°C with 5% CO2, mimicking the physiological conditions of the retina.

  • What is the significance of Human Retinal Astrocytes in retinal neurovascular coupling?

    Retinal astrocytes play a key role in neurovascular coupling, which is the process by which neuronal activity regulates blood flow in the retina. They mediate communication between neurons and blood vessels, ensuring adequate blood supply in response to retinal activity.

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Tags

  • Astrocyte (31)
  • Human (1729)
  • Normal (1578)
  • Ocular (18)

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