Renal proximal tubule cells (RPTCs) form single-layer epithelium that covers the basement membrane. They are responsible for the reabsorption of most solutes from the glomerular filtrate and the excretion of metabolic wastes and xenobiotics into the tubule lumen. RPTCs exhibit apicobasal polarity, which is essential for renal filtration. Renal proximal convoluted tubule epithelial cells express different enzymes in the urine and are involved in drug transportation and metabolism. RPTCs are sensitive to injury. When exposed to toxic or ischemic conditions, their death can lead to acute or chronic kidney disease.
Why choose Human Renal Proximal Tubule Cells (HRPTCs) from AcceGen?
HRPTCs are isolated from human kidneys using AcceGen’s advanced technology. Cells at passage one are cryopreserved to ensure the best viability. Each vial contains more than 5×10^5 cells in 1ml volume. HRPTCs are characterized by the expression of cytokeratin-18 and/or -19 using immunofluorescence. HRPTCs are guaranteed for further expansion of at least 15 doublings following protocols provided by AcceGen.
