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Human Renal Interstitial Fibroblasts | ||||
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| Product Name | Human Renal Interstitial Fibroblasts | |||
| Price | Get Quote | |||
| Cat.No | ABC-TC095L | Species | Human | |
| Cell Type | Fibroblast | |||
| Growth Mode | Adherent | |||
| Size/Quantity | 1 vial | Biosafety Level | 1 | |
| Shipping Info | Dry Ice | Storage | Liquid Nitrogen | |
| Description | Human renal interstitial fibroblasts play a crucial role in regulating systemic oxygen delivery through the production of renin and erythropoietin (Epo). These fibroblasts increase renin production in response to both acute and chronic anemia, as well as fluctuations in blood pressure. Epo production stimulates erythropoiesis, particularly during anemia-induced hypotension. Additionally, in response to kidney injury, renal interstitial fibroblasts can differentiate into myofibroblasts, contributing to renal fibrosis. Interestingly, during urinary tract infections caused by uropathogenic Escherichia coli, human renal fibroblasts exhibit strong immunomobilizing capabilities, highlighting their active role in immune responses.
Why choose Human Renal Interstitial Fibroblasts from AcceGen? Our cells undergo rigorous quality control to guarantee their integrity and functionality. They are mycoplasma-free, providing a reliable foundation for experimental accuracy. Additionally, our fibroblasts exhibit consistent morphology with limited passage, ensuring reproducibility in your studies. | |||
| Disease | Normal | |||
| Source Organ | Kidney | |||
| Quality Control | All cells test negative for mycoplasma, bacteria, yeast, and fungi. | |||
| Recommended Medium And Supplement | ABM-TM095L Human Renal Interstitial Fibroblasts Medium Kit | |||
| Citation Guide | When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID). | |||
| Application | FOR RESEARCH USE ONLY Human renal interstitial fibroblasts are essential for researching kidney fibrosis, particularly in understanding post-transplant anemia incidence and the mechanisms underlying renal interstitial fibrosis. These fibroblasts are utilized to investigate their in vitro growth, differentiation, and collagen synthesis in kidneys affected by interstitial fibrosis. This research aids in elucidating the mechanisms that trigger the induction and progression of renal interstitial fibrosis in vivo, providing insights into potential therapeutic strategies. By studying these cells, researchers can develop targeted treatments to mitigate kidney damage and improve patient outcomes in conditions associated with fibrosis. | |||
| Growth Conditions | 37 ℃, 5% CO2 | |||
| Product Type | Renal Cells | |||
| Product Image |  | |||
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Frequently Asked Questions
What are Human Renal Interstitial Fibroblasts?
Human Renal Interstitial Fibroblasts are specialized fibroblast cells located in the interstitial space of the kidneys. They play a key role in maintaining the structural integrity of kidney tissue and are involved in the production of extracellular matrix proteins, which provide support to renal cells and blood vessels.
What are the primary functions of Human Renal Interstitial Fibroblasts?
The primary functions of these fibroblasts include the production of extracellular matrix components like collagen and fibronectin, which help maintain kidney structure. Additionally, they play a crucial role in wound healing, fibrosis, and tissue remodeling, especially during kidney injury or chronic kidney disease.
What role do Human Renal Interstitial Fibroblasts play in kidney fibrosis?
During kidney injury or chronic disease, Renal Interstitial Fibroblasts become activated and transform into myofibroblasts, which are involved in the overproduction of extracellular matrix. This leads to fibrosis, or scarring, which can impair kidney function over time.
What are Human Renal Interstitial Fibroblasts used for in research?
These cells are used in studies related to kidney fibrosis, chronic kidney disease, tissue engineering, and drug discovery. They are essential for understanding the mechanisms behind renal fibrosis and developing treatments that target fibrotic processes in the kidney.
Are there specific markers used to identify Human Renal Interstitial Fibroblasts?
Yes, Human Renal Interstitial Fibroblasts express specific markers, including vimentin, fibronectin, and α-smooth muscle actin (α-SMA) when activated. These markers help distinguish them from other cell types in the kidney, particularly when studying fibrosis and tissue remodeling.
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