Human renal interstitial fibroblasts play a crucial role in regulating systemic oxygen delivery through the production of renin and erythropoietin (Epo). These fibroblasts increase renin production in response to both acute and chronic anemia, as well as fluctuations in blood pressure. Epo production stimulates erythropoiesis, particularly during anemia-induced hypotension. Additionally, in response to kidney injury, renal interstitial fibroblasts can differentiate into myofibroblasts, contributing to renal fibrosis. Interestingly, during urinary tract infections caused by uropathogenic Escherichia coli, human renal fibroblasts exhibit strong immunomobilizing capabilities, highlighting their active role in immune responses.
Why choose Human Renal Interstitial Fibroblasts from AcceGen?
Our cells undergo rigorous quality control to guarantee their integrity and functionality. They are mycoplasma-free, providing a reliable foundation for experimental accuracy. Additionally, our fibroblasts exhibit consistent morphology with limited passage, ensuring reproducibility in your studies.
