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Human Renal Glomerular Endothelial Cells

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Renal glomerular endothelial cells (GEC) are a specialized microvascular cell type involved in the regulation of glomerular ultrafiltration. They form the inner part of the filtration barrier and are involved in pathophysiological processes in the glomerulum. They constitutively synthesize bio-active molecules, to which this basal activity can be chronically augmented by various inflammatory and thrombotic […]
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Home | Primary Cells | Human Primary Cells | Urinary System Primary Cells | Human Renal Glomerular Endothelial Cells
Product Code

HRGEC
Species

Human
Cat.No

ABC-TC3783
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Endothelial
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Kidney
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Renal Cells

Description

Human Renal Glomerular Endothelial Cells (HRGEC), derived from healthy human kidneys, are specialized microvascular cells vital for regulating glomerular ultrafiltration and linked to glomerular diseases. They form the continuous inner lining of glomerular capillaries, characterized by a unique cytoplasmic structure with fenestrae (circular transcellular pores) crucial for high hydraulic conductivity. HRGEC injuries impact mesangial and epithelial cells, Human Renal Glomerular Endothelial Cellscontributing to renal disease progression in conditions like haemolytic uraemic syndrome and pre-eclampsia. Diseases involving glomerular capillary destruction, such as haemolytic uraemic syndrome and vasculitis, rely on HRGEC angiogenesis for recovery. These cells originate from vasculogenesis in mesenchymal precursors, predominantly, and in-growth of existing vessels.

 

Why choose Human Renal Glomerular Endothelial Cells from AcceGen?

HRGEC are cryopreserved at their first passage and delivered in frozen vials, with over 0.5×106 viable cells per vial. They can reliably expand for 15 population doublings following provided instructions, making them a valuable resource for renal research.

AcceGen Frozen Cells & Cell Lines 1 vial
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Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Zhang, L., Wang, J. Sinomenine alleviates glomerular endothelial permeability by activating the C/EBP-α/claudin-5 signaling pathway. Human Cell 35, 1453–1463 (2022). https://doi.org/10.1007/s13577-022-00750-0

Application

  • FOR RESEARCH USE ONLY

  • Human Renal Glomerular Endothelial Cells (HRGEC) cultured in vitro serve as valuable models for investigating the intricate relationship between endothelial cells and renal diseases. These cells are essential tools for establishing in vitro disease models suitable for high throughput and high content screening. Studying human GEnC through these cultures aids in gaining a comprehensive understanding of glomerular filtration, glomerular diseases, responses to glomerular injuries, and the potential for therapeutic interventions in these contexts. While some responses necessitate in vivo studies, cell cultures enable a meticulous examination of individual cell behaviors and the actions and interactions of specific mediators, facilitating critical insights into renal health and pathology.

Frequently Asked Questions

  • What are Human Renal Glomerular Endothelial Cells?

    Human Renal Glomerular Endothelial Cells (HRGECs) are specialized endothelial cells that line the capillaries within the glomerulus, the functional unit of the kidney responsible for blood filtration. They form part of the glomerular filtration barrier, which selectively filters blood plasma to produce urine while retaining essential proteins and cells.

  • How to study Human Renal Glomerular Endothelial Cells in research and clinical settings?

    Human Renal Glomerular Endothelial Cells (HRGECs) are studied using in vitro cell culture models, animal models, and human tissue samples to understand their biology, function, and role in kidney diseases. Researchers also explore potential therapeutic strategies targeting HRGECs to treat or prevent renal disorders and improve kidney health.

  • What are the benefits of using Human Renal Glomerular Endothelial Cells in research?

    Human Renal Glomerular Endothelial Cells (HRGECs) serve as a valuable tool for dissecting the molecular and cellular mechanisms underlying kidney diseases. By studying HRGEC biology, researchers can uncover novel signaling pathways, biomarkers, and therapeutic targets implicated in renal pathophysiology, thus advancing our understanding and treatment of kidney disorders.

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