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Human Pulmonary Pericytes

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Human Pulmonary Pericytes are distributed in the microvasculature of lung tissue, key factors of regulating angiogenesis, stability, and function. Pericytes are typically characterized by a prominent nucleus with less cytoplasm around the nucleus and many protrusions parallel to the long axis of the microvessel, which taper and surround the microvascular lumen to support the lumen. […]
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Home | Primary Cells | Human Primary Cells | Respiratory System Primary Cells | Human Pulmonary Pericytes

Pulmonary pericytes are specialized mesenchymal cells embedded within the alveolar capillary basement membrane. They envelop capillaries and have processes forming focal contact with endothelial cells. Pericytes in the lung help maintain structural integrity and contribute to vascular repair after lung injury. Lung pericytes can sense danger signals and amplify inflammatory responses by elaborating cytokines. Disruption in pericyte-endothelial cell interaction (PDGF-PDGFRβ signaling axis) can lead to abnormal vasculogenesis in early embryonic development.

Why choose Human Pulmonary Pericytes from AcceGen?

Human pulmonary pericytes are derived from healthy human lungs with fully consented donors using AcceGen’s advanced technology. Cells are immediately cryopreserved to ensure the best viability. Each vial contains more than 5×10^5 cells in 1ml volume. Human pulmonary pericytes are quality tested with the expression of platelet-derived growth factor-ß (PDGFRß) and α-smooth muscle actin by immunofluorescence.

Species

Human
Cat.No

ABC-H0044X
Quality Control

All cell lots test negative for HIV-1, HBV, HCV, mycoplasma, yeast, fungi, and other pathogens.
Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Pericyte
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Lung
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Pulmonary Cells

Citation

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AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • Growing evidence suggests a central role for pericytes as myofibroblast precursors, contributing to the development of lung disorders such as fibrosis and asthma. Human pulmonary pericytes provide an easily accessible model for studying the biology and pathophysiology of primary pericytes. Studying the interactions between pericytes and endothelial cells, pericytes and other pulmonary cells may provide novel insight into pulmonary circulation and the pathogenesis of lung disorders.

Frequently Asked Questions

  • What are pulmonary pericytes?

    Pulmonary pericytes are specialized contractile cells found wrapped around the endothelial cells of capillaries and venules in the lungs. They play a crucial role in maintaining blood vessel stability, regulating blood flow, and supporting the endothelial cells.

  • What is the primary function of pulmonary pericytes?

    The primary function of pulmonary pericytes is to provide structural support to blood vessels, regulate blood-brain barrier integrity, influence blood flow, and participate in the repair and regeneration of the vasculature in the lungs.

  • Is dysfunction of pulmonary pericytes associated with the development of pulmonary diseases?

    Yes, dysfunction of pulmonary pericytes is closely related to pulmonary diseases such as pulmonary hypertension, fibrosis, and chronic obstructive pulmonary disease (COPD). Their malfunction can lead to abnormal vascular remodeling, inflammation, and tissue scarring, exacerbating the progression of these conditions.

  • How do pulmonary pericytes interact with endothelial cells?

    Pulmonary pericytes interact with endothelial cells through direct physical contact and paracrine signaling. These interactions are essential for blood vessel stability, regulation of permeability, and angiogenesis.

  • What signaling pathways are involved in pulmonary pericyte function?

    Key signaling pathways involved in pulmonary pericyte function include the PDGF (platelet-derived growth factor) pathway, TGF-β (transforming growth factor-beta) pathway, and Notch signaling. These pathways regulate pericyte proliferation, migration, and differentiation.

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Tags

  • Human (1729)
  • Normal (1578)
  • Pericyte (4)
  • Pulmonary (23)

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