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Primary Cells

Human Pulmonary Pericytes

  • For research use only

Cat No.

ABC-H0044X
Product Type

Pulmonary Cells
Cell Type

Pericyte
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

Lung
Disease

Normal
Storage

Liquid Nitrogen

Human Pulmonary Pericytes regulate angiogenesis, microvascular stability, and barrier properties, supporting lung vascular biology and disease research.

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  • Human Pulmonary Pericytes
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Home | Primary Cells | Human Primary Cells | Respiratory System Primary Cells | Human Pulmonary Pericytes

Description

Human pulmonary pericytes are mesenchymal cells derived from the microvasculature of normal human lung tissue. These cells exhibit a spindle-shaped, fibroblast-like morphology and grow adherently under standard culture conditions. For optimal performance, they are isolated at early passages. These cells are non-immortalized and can only undergo limited in vitro expansion. Pulmonary pericytes play essential roles in angiogenesis, capillary integrity maintenance, vascular remodeling, and immune modulation in the lung. They respond to injury by releasing proinflammatory cytokines and regulate the PDGF-PDGFRβ signaling axis, crucial for vasculature repair. Dysregulation of these cells is associated with pulmonary fibrosis and chronic lung inflammation. The cells show a normal human karyotype, and markers such as PDGFRβ, NG2, and CD146 are expressed.

Species

Human
Cat.No

ABC-H0044X
Quality Control

All cell lots test negative for HIV-1, HBV, HCV, mycoplasma, yeast, fungi, and other pathogens.
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Pericyte
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Lung
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Pulmonary Cells
Key Features

– Backed by AcceGen advanced technology
– Cryopreserved for highest viability and plating efficiency
– Quality-guaranteed for accurate results
– Timely technical support for best experimental outcomes

Application

  • Human pulmonary pericytes serve as an ideal in vitro model for studying lung disease mechanisms, particularly in fibrosis and asthma, due to their role as key myofibroblast precursors. These cells enable researchers to investigate pericyte-endothelial interactions, pulmonary vascular dysfunction, and disease progression, offering potential for high-throughput drug screening and the development of novel therapeutic strategies for respiratory disorders.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Frequently Asked Questions

  • What are pulmonary pericytes?

    Pulmonary pericytes are specialized contractile cells found wrapped around the endothelial cells of capillaries and venules in the lungs. They play a crucial role in maintaining blood vessel stability, regulating blood flow, and supporting the endothelial cells.

  • What is the primary function of pulmonary pericytes?

    The primary function of pulmonary pericytes is to provide structural support to blood vessels, regulate blood-brain barrier integrity, influence blood flow, and participate in the repair and regeneration of the vasculature in the lungs.

  • Is dysfunction of pulmonary pericytes associated with the development of pulmonary diseases?

    Yes, dysfunction of pulmonary pericytes is closely related to pulmonary diseases such as pulmonary hypertension, fibrosis, and chronic obstructive pulmonary disease (COPD). Their malfunction can lead to abnormal vascular remodeling, inflammation, and tissue scarring, exacerbating the progression of these conditions.

  • How do pulmonary pericytes interact with endothelial cells?

    Pulmonary pericytes interact with endothelial cells through direct physical contact and paracrine signaling. These interactions are essential for blood vessel stability, regulation of permeability, and angiogenesis.

  • What signaling pathways are involved in pulmonary pericyte function?

    Key signaling pathways involved in pulmonary pericyte function include the PDGF (platelet-derived growth factor) pathway, TGF-β (transforming growth factor-beta) pathway, and Notch signaling. These pathways regulate pericyte proliferation, migration, and differentiation.

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