Human Prostate Stromal Cells

Human Prostate Stromal Cells are primary human cells characterized by their bipolar morphology, crucial for the glandular function of generating fluid with essential roles in reproduction. When stimulated by TGF-β, these cells express various growth factors and cytokines, such as IL-6 and BMP-6, which synergistically induce androgen receptor (AR) activation when co-cultured with prostate cancer cells. Additionally, these stromal cells express the progesterone receptor, enabling them to regulate cancer cell mobility. Moreover, estrogen plays a role in promoting the proliferation of human prostate stromal cells through the activation of the ERK pathway, further emphasizing their significance in prostate physiology and pathology.

Why choose Human Prostate Stromal Cells from AcceGen?

Choosing Human Prostate Stromal Cells from AcceGen ensures high quality and reliable performance. These cells are guaranteed through 15 population doublings and exhibit positive vimentin staining and negative pan cytokeratin staining. With cryopreservation at third or fourth passage, the cells arrive in optimal condition. Additionally, rigorous testing confirms the absence of mycoplasma, bacteria, yeast, and fungi, while HIV-1, hepatitis B, and hepatitis C are not detected in all donors and/or cell lots.