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Human Pancreatic Islets of Langerhans Cells

Product Name

Human Pancreatic Islets of Langerhans Cells

Price Get Quote
Cat.No

ABC-TC4286

Species

Human

Size/Quantity

1 vial

Biosafety Level

1

Shipping Info

Dry Ice

Storage

Liquid Nitrogen

Description

Human Pancreatic Islets of Langerhans Cells or pancreatic islets cells, first discovered in the late-nineteenth century, are the regions of pancreas which contain endocrine cells producing hormone. Islet cells are innervated by sympathetic, parasympathetic, and sensory nerves. Although the islets only account for less than 2% of pancreatic mass, they are highly vascularized so that they can quickly secrete insulin in response to change glucose in blood. In addition, pancreatic islet cells can receive almost 10-15% of the blood-flow to the pancreas.
Langerhans cells are dense clusters of cells in the pancreas, comprising of different cell types. Pancreatic beta cells (or β cells) which function in insulin-secreting, are the most abundant islet cell type, encompassing around 60% of a human islet. There are also pancreatic alpha cells (or α cells) secreting glucagon, Delta cells (δ cells or D cells) secreting somatostatin, Epsilon cells (ε cells) secreting ghrelin and pancreatic PP cells that secret polypeptide. Those pancreatic cells together act on the maintenance of glucose homeostasis and other aspects of metabolism.

Why Choose Human Pancreatic Islets of Langerhans Cells from AcceGen?
The purification of pancreas islet cells is difficult to undertake as the islets locate in diffuse clusters of cells within the exocrine pancreas. AcceGen Human Pancreatic Islets of Langerhans cells are maintained in AcceGen Human Pancreatic Islets of Langerhans Cell Culture Complete Growth Medium and Human Pancreatic Islets of Langerhans Cell Culture Extracellular Matrix.
All donors from which the cells were derived were pre-screened; Donors are tested negative for the usual blood donation infectious disease panel ABO/RH, Hepatitis B Surface Antigen, HIV1 and 2, Syphilis, hepatitis B Core, Human T Lymphocyte Virus 1 and 2, Hepatitis C Virus, Antibody Screen, Nucleic Amplification Test for HIV 1 HCV, West Nile Virus and Antibodies to Trypanosoma cruzi (the agent of Chagas disease).

Human Pancreatic Type 1 Diabetic Islets of Langerhans and Human Pancreatic Type 2 Diabetic Islets of Langerhans are also available in AcceGen.

Disease

Normal

Source Organ

Pancreatic Islet

Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Recommended Medium And Supplement

ABM-TM4286 Human Pancreatic Islets of Langerhans Cells Medium Kit

Citation Guide

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
Uddin, M., Li, Y., Khan, H.Y., Muqbil, I., Aboukameel, A., Sexton, R.E., Reddy, S., Landesman, Y., Kashyap, T., Azmi, A.S. and Heath, E.I., 2021. Nuclear Export Inhibitor KPT-8602 Synergizes with PARP Inhibitors in Escalating Apoptosis in Castration Resistant Cancer Cells. International journal of molecular sciences, 22(13), p.6676.

Application

For research use only

Key Features

-Backed by AcceGen advanced technology
-Cryopreserved for highest viability and plating efficiency
-Quality-tested for accurate results

Growth Conditions

37 ℃, 5% CO2

Cell Type

Langerhans Cell

Growth Mode

Adherent

Product Type

Pancreatic Cells

Product Image AcceGen Frozen Cells & Cell Lines 1 vial

Frequently Asked Questions

  • What is the source of Human Pancreatic Islets of Langerhans Cells?

    These cells are isolated from the pancreas of healthy human donors or patients with diabetes.

  • Can Human Pancreatic Islets of Langerhans Cells be used for diabetes research?

    Yes, they are ideal for studying insulin secretion, glucose metabolism, and diabetes-related mechanisms.

  • What culture medium is recommended for Human Pancreatic Islets of Langerhans Cells?

    A specialized pancreatic islet medium supplemented with appropriate growth factors is recommended.

  • Are Human Pancreatic Islets of Langerhans Cells suitable for drug discovery in diabetes treatments?

    Yes, these cells are commonly used in drug discovery and testing for potential diabetes therapies.

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Reviews of Human Pancreatic Islets of Langerhans Cells
AcceGen is always trying to do right by our customers and working hard to build a higher quality product.

One thought on “Human Pancreatic Islets of Langerhans Cells”


Date: 03-30-2022 09:42:56


This AcceGen product was quite impressive. These cells arrived on time and with a complete kit containing all necessary information with the requisite media for culture. All questions I had were answered within this information kit. When we finally cultured the Human Pancreatic Islets of Langerhans Cells - they behaved exquisitely. They cultured great for about ~7days and then performed very well both through FACS analysis and within the GSIS assay. Through FACS analysis, we compared these as a positive control to our porcine Islet cells and looked for INS+ and GCG+ populations. They performed quite well through GSIS analysis as well. Highly recommend.


Quote No.: AGK1905 Name: David Grosh

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