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Human Pancreatic Fibroblasts

  • BSL
  • 110
Human Primary Pancreatic Fibroblasts are isolated from normal human pancreatic tissue. Human Primary Pancreatic Fibroblasts are grown in T75 tissue culture flasks pre-coated with gelatin-based coating solution for 2 min and incubated in AcceGen’s Culture Complete Growth Medium generally for 3-7 days. Cultures are then expanded. Prior to shipping, cells at passage 1 are detached […]
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Home | Primary Cells | Human Primary Cells | Endocrine System Primary Cells | Human Pancreatic Fibroblasts

Pancreatic fibroblasts are mesenchymal cells found in periacinar, perivascular and periductal regions of pancreas with an essential role in structural support and would healing. Increasing evidences have suggested that pancreas harbours a heterogenous population of fibroblasts with distinct functions and expression patterns. The potential of pancreatic associated fibroblasts to promote fibrosis and develop into fibroinflammatory stroma is commonly associated with pancreatic diseases such as pancreatic ductal adenocarcinoma (PDA).
Why choose Human Pancreatic Fibroblasts from AcceGen?
Human Pancreatic Fibroblasts are cryopreserved at passage 1 immediately after purification and delivered in dry ice. Each vial contains > 5×10^5 cells in 1 ml volume. Human pancreatic fibroblasts are not detected with HIV-1, HBV, HCV and other pathogens. Cells are characterized to positively express desmin and GFAP by immunofluorescence. Cells are tested negative for von Willebrand Factor Expression/Factor VIII, cytokeratin 18, and alpha smooth muscle actin. Human pancreatic fibroblasts are guaranteed to further expand for 3-5 passages following AcceGen recommended cell culture protocols.

Species

Human
Cat.No

ABC-TC5470
Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Fibroblast
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Pancreas
Disease

Normal
Storage

Liquid Nitrogen
Product Type

Pancreatic Cells

Citation

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Application

  • For research use only

  • Human pancreatic fibroblasts provide an ideal model for studying the heterogeneity of pancreatic fibroblast populations, as wells as their potential role in pancreatic injury and pancreatic cancer. They can also be used to investigate the origin and molecular characteristics of pancreatic cancer-associated fibroblasts.

Frequently Asked Questions

  • What are Human Pancreatic Fibroblasts?

    Human pancreatic fibroblasts are specialized cells located in the pancreas that provide structural support and produce extracellular matrix components. They play a crucial role in maintaining the tissue architecture and function of the pancreas.

  • What is the primary function of pancreatic fibroblasts?

    The primary function of pancreatic fibroblasts is to synthesize and remodel the extracellular matrix, support pancreatic tissue structure, and facilitate tissue repair and regeneration. They also play a role in modulating inflammation and fibrosis.

  • How do pancreatic fibroblasts affect the tumor microenvironment?

    In the tumor microenvironment, pancreatic fibroblasts (often referred to as cancer-associated fibroblasts, or CAFs) secrete growth factors, cytokines, and extracellular matrix components that support tumor cell survival, proliferation, and invasion. They also contribute to the development of a fibrotic stroma that can impede drug delivery.

  • What are the therapeutic uses of targeting pancreatic fibroblasts?

    Therapeutic applications include developing drugs that target fibroblast activity to reduce fibrosis and improve pancreatic function in diseases like chronic pancreatitis. In pancreatic cancer, targeting fibroblasts and their interactions with cancer cells could enhance the effectiveness of cancer treatments and inhibit tumor progression.

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Tags

  • Fibroblast (273)
  • Human (1729)
  • Normal (1578)
  • Pancreatic (9)

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