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Human Pancreatic CAF-Stellate Cells

  • BSL
  • 101
Pancreatic cancer remains one of the most deadly and least survivable cancers; it is asymptomatic until quite advanced and is resistant to conventional therapies. It has recently become apparent that cancer tumor cells are closely associated with other cells called cancer-associated fibroblasts or CAFs. These cells promote the malignant process and block immune surveillance. CAFs […]
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Home | Primary Cells | Human Primary Cells | Endocrine System Primary Cells | Human Pancreatic CAF-Stellate Cells
Species

Human
Cat.No

ABC-TC5543
Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Stellate Cell
Shipping Info

Dry ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Pancreas
Storage

Liquid Nitrogen
Product Type

Human Primary Carcinoma Associated Fibroblasts

Description

Human Pancreatic CAF-Stellate Cells are cancer-associated fibroblasts (CAFs) derived from pancreatic stellate cells (PSCs) and play a crucial role in the tumour microenvironment (TME). Human Pancreatic CAF-Stellate CellsCAFs are activated fibroblastic cells found in the solid cancer microenvironment, exhibiting distinct phenotypes, functions, and locations compared to quiescent fibroblasts. In pancreatic cancer, PSCs are a significant source of CAFs. Once activated, PSC-derived CAFs lose their lipid droplet expression. These cells contribute to pancreatic fibrogenesis and hypoxia by producing extracellular matrix (ECM) proteins. Importantly, the deletion of CAFs has been shown to have tumor-promoting effects, highlighting their significant impact on pancreatic cancer progression.

(Image by macrovector on Freepik)

 

Why choose Human Pancreatic CAF-Stellate Cells from AcceGen?

Choosing Human Pancreatic CAF-Stellate Cells from AcceGen offers several advantages. These cells are of high quality, sterile, and cryopreserved at a low passage, ensuring their viability and functionality upon arrival. AcceGen provides cells at passage 1, detached from flasks and immediately cryopreserved in vials. With high passage capabilities, these cells can be expanded for 3-5 passages, allowing for extended experimental use and increased flexibility in research applications.

AcceGen Frozen Cells & Cell Lines 1 vial
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Citation

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Application

  • FOR RESEARCH USE ONLY

  • Human Pancreatic CAF-Stellate Cells have significant applications in understanding and targeting pancreatic cancer. CAFs play a crucial role in the progression and drug resistance of pancreatic cancer. Targeting these cancer-associated fibroblasts has emerged as a promising therapeutic strategy. Human Pancreatic CAFs can be implicated in various aspects of solid tumor biology, such as neoplastic progression, tumor growth, angiogenesis, and metastasis. By isolating and studying Human Pancreatic CAFs, researchers can gain insights into the heterogeneity of cancer-associated fibroblasts, leading to the development of more specific and personalized therapies for pancreatic cancer patients in the future.

Frequently Asked Questions

  • What are Human Pancreatic CAF-Stellate Cells?

    Human pancreatic CAF-stellate cells are cancer-associated fibroblasts (CAFs) derived from pancreatic tissue. They play a significant role in the tumor microenvironment by interacting with cancer cells, influencing tumor growth, progression, and metastasis.

  • What is the distinction between human pancreatic CAF-stellate cells and traditional stellate cells?

    Human pancreatic CAF-stellate cells are fibroblasts found in pancreatic cancer tissues, not traditional stellate cells involved in fibrosis. Stellate cells are a separate cell type primarily associated with fibrosis and are not specifically linked to cancerous conditions in the pancreas.

  • What is the primary function of pancreatic CAF-stellate cells in cancer?

    The primary function of pancreatic CAF-stellate cells in cancer is to remodel the extracellular matrix, promote tumor cell proliferation, facilitate immune evasion, and enhance angiogenesis, thereby supporting tumor growth and metastasis.

  • How to isolate pancreatic CAF-stellate cells from tumor tissues?

    Pancreatic CAF-stellate cells are typically isolated from pancreatic tumor tissues through enzymatic digestion followed by cell culture techniques that allow the fibroblasts to proliferate while other cell types are minimized.

  • What are the research applications of pancreatic CAF-stellate cells?

    Pancreatic CAF-stellate cells are used in research to study tumor-stroma interactions, investigate the mechanisms of fibrosis in the pancreas, develop anti-cancer therapies targeting the tumor microenvironment, and understand the role of CAFs in cancer resistance to treatments.

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