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Human Ovarian Surface Epithelial Cells | ||||
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| Product Name | Human Ovarian Surface Epithelial Cells | |||
| Price | Get Quote | |||
| Product Code | HOSEpiC | |||
| Cat.No | ABC-TC3743 | Species | Human | |
| Size/Quantity | 1 vial | Biosafety Level | 1 | |
| Shipping Info | Dry Ice | Storage | Liquid Nitrogen | |
| Description |
Why choose Human Ovarian Surface Epithelial Cells from AcceGen? Human Ovarian Surface Epithelial Cells from AcceGen are cryopreserved at passage one and supplied frozen, with each vial containing over 5×105 cells in 1 ml volume. These cells are identified through immunofluorescence using antibodies targeting cytokeratin-18 and/or cytokeratin-19. They have been thoroughly screened and confirmed to be negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi. Furthermore, they are guaranteed to undergo five population doublings under the specified AcceGen’s conditions. | |||
| Disease | Normal | |||
| Source Organ | Ovarian | |||
| Quality Control | All cells test negative for mycoplasma, bacteria, yeast, and fungi. | |||
| Recommended Medium And Supplement | ABM-TM3743 Human Ovarian Surface Epithelial Cells Medium Kit | |||
| Citation Guide | When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID). | |||
| Application | FOR RESEARCH USE ONLY Human Ovarian Surface Epithelial Cells find valuable applications in scientific research, particularly in investigating the pathogenesis of epithelial ovarian cancer. Studies focused on the ovarian surface epithelium and its structural changes following ovulation, as well as their presence in ovarian carcinomas, are essential for this purpose. Gaining insights into the abnormalities in cellular pathways is clinically significant as it helps in understanding OSE cell survival, apoptosis, transformation, and function during disease progression, ultimately offering potential markers for disease treatment and management. | |||
| Growth Conditions | 37 ℃, 5% CO2 | |||
| Cell Type | Epithelial | |||
| Growth Mode | Adherent | |||
| Product Type | Female Reproductive Cells | |||
| Product Image |  | |||
Human Ovarian Surface Epithelial Cells are primary cells derived from the outer layer of the human ovary. In vivo, they display a diverse morphology ranging from squamous to cuboidal to low columnar. These cells play an active role in cyclical ovulatory follicular rupture and subsequent repair. They express various peptide hormones, sex steroids, growth factors, and receptors. Notably, when co-cultured with endometrial stromal cells in an estrogen-rich environment, these cells exhibit gland formation. Moreover, when cultured on two layers of extracellular matrix and collagen gel, they demonstrate a mesenchymal property, reflecting their phenotypic plasticity.Frequently Asked Questions
What are Human Ovarian Surface Epithelial Cells?
Human Ovarian Surface Epithelial Cells are the layer of cells that cover the surface of the ovary. They are involved in the ovulation process and are the origin of most ovarian cancers, making them significant in both reproductive biology and cancer research.
What functions do Human Ovarian Surface Epithelial Cells perform?
Human Ovarian Surface Epithelial Cells play a role in protecting the ovary and participate in the ovulation process by covering the ovarian surface. They also undergo cyclic changes in response to hormonal fluctuations and are involved in the repair of the ovarian surface after ovulation.
What are the common research applications of Human Ovarian Surface Epithelial Cells?
These cells are used in research to study ovarian biology, the mechanisms of ovulation, and the pathogenesis of ovarian cancer. They are also important for exploring the effects of hormones on ovarian function and for developing targeted therapies for ovarian cancer.
How do Human Ovarian Surface Epithelial Cells relate to ovarian cancer?
The majority of ovarian cancers are believed to originate from Human Ovarian Surface Epithelial Cells. Studying these cells can provide insights into the early events of ovarian carcinogenesis, helping to identify potential biomarkers and therapeutic targets for ovarian cancer.
Can Human Ovarian Surface Epithelial Cells be used in drug screening?
Yes, Human Ovarian Surface Epithelial Cells can be used in drug screening, particularly for testing the effects of chemotherapeutic agents or targeted therapies on ovarian cells. They provide a relevant model for assessing the response of ovarian tissue to various treatments.
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