Human Ovarian Fibroblasts

Human Ovarian Fibroblasts are isolated from healthy human ovaries and serve crucial functions in tissue maintenance. They are responsible for synthesizing components of the extracellular matrix, supporting the structural integrity of connective tissues, and actively participating in wound healing processes. In the presence of ovarian cancer cells, these fibroblasts within the stroma undergo significant structural and biochemical changes. Ovarian cancer cells prompt normal ovarian fibroblasts to release a diverse range of peptides, including growth factors, chemokines, collagens, and matrix-modifying enzymes, creating a pro-tumorigenic and anti-immunogenic microenvironment that facilitates cancer progression and metastasis.

Why choose Human Ovarian Fibroblasts from AcceGen?

AcceGen’s Human Ovarian Fibroblasts are cryopreserved at passage one, with each vial containing over 500,000 viable cells in 1mL volume. They exhibit spindle morphology and are fibronectin-positive. The cells are free from HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi, ensuring their safety. Additionally, they can undergo up to 15 population doublings as per provided instructions, making them an ideal tool for research and experimentation.