and osteoclasts, accountable for bone resorption. Osteoclasts, multinucleated cells that absorb bone, originate from pluripotential hematopoietic stem cells and share precursor cells with the mononuclear phagocyte system. The ligand RANKL, produced by osteoblasts, along with M-CSF, facilitates the development of active osteoclasts when introduced to osteoclast precursor cultures. Retinoic Acid enhances the proliferation of human osteoclast progenitors and hinders RANKL-induced osteoclast differentiation by suppressing the RANK receptor.
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