Human orbital fibroblasts, isolated from the connective tissue of the orbit, are distinct from fibroblasts derived from dermal and other extraorbital sources. In culture, they exhibit unique responses to stimuli, such as binding endothelin and producing high levels of IL-6 upon IL-1β treatment, linking them to inflammation and immune responses. These fibroblasts play a crucial role in Graves’ ophthalmopathy (GO), where excessive activity contributes to disease pathogenesis. Activated by immune cell interactions and soluble factors, orbital fibroblasts express the thyrotropin receptor (TSHR), with autoantibodies targeting TSHR potentially linking Graves’ disease and GO through proinflammatory cytokine production.
Why choose Human Orbital Fibroblasts from AcceGen?
AcceGen ensures Human Orbital Fibroblasts are from expert isolation and cryopreserved at an early passage, which helps maintain cell integrity and functionality. The cells exhibit high viability, making them ideal for research purposes. AcceGen also provides fast and reliable transport to preserve cell quality, ensuring they arrive in optimal condition.
