Oral keratinocytes act as the major barrier to physical, microbial, and chemical agents that may cause local cell injury. They are involved in the proinflammatory process through the production of cytokines either constitutively or after a variety of stimuli, implying that they may potentially participate in controlling oral infections through an inflammatory process involving different […]
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Human Oral Keratinocytes (HOK), obtained from the lining mucosa of the human oral cavity, serve as a crucial line of defense against physical, microbial, and chemical threats in the oral environment. They actively contribute to the inflammatory response by secreting cytokines like IL-1β and IL-18, either constitutively or in response to various stimuli, potentially assisting in the management of oral infections. Furthermore, these keratinocytes display distinctive differentiation markers, with their gene transcription subject to calcium-induced alterations, showcasing their adaptability to environmental challenges. With notable structural and functional parallels to dermal keratinocytes, HOK underscore their pivotal role in maintaining oral health and regulating the immune system.
Why choose Human Oral Keratinocytes from AcceGen?
Human Oral Keratinocytes(HOK) are cryopreserved at passage one, supplied in frozen vials with over 5×105 viable cells per vial. These cells undergo rigorous quality testing to confirm their ability to exhibit proper growth and maintain morphology for a minimum of 10 population doublings, ensuring their reliability and utility in various research applications.
Product Code
HOK
Species
Human
Cat.No
ABC-TC3733
Quality Control
All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category
Primary Cells
Size/Quantity
1 vial
Cell Type
Keratinocyte
Shipping Info
Dry Ice
Growth Conditions
37 ℃, 5% CO2
Source Organ
Oral
Disease
Normal
Biosafety Level
1
Storage
Liquid Nitrogen
Product Type
Oral Cells
Citation
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
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Application
FOR RESEARCH USE ONLY
Human Oral Keratinocytes (HOK) offer a versatile serum-free culture model with a wide range of applications. They are invaluable for investigating microbial-to-epithelial cell interactions, unraveling the dynamics of growth factors, exploring wound healing mechanisms, delving into toxicology studies, and deepening our understanding of oral epithelial biology. Additionally, HOK serve as valuable tools for the examination of fundamental keratinocyte biology and the intricate processes of immortalization and malignant transformation, making them essential in both basic research and clinical contexts.
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