Human Monocytes

Human monocytes are mononuclear cells with kidney- or bean-shaped nuclei that circulate in blood, bone marrow and spleen. They can sense inflammation lesion through chemokine receptors and pathogen recognition receptors and initiate immune defense by differentiating into macrophages or dendritic cells. Human peripheral blood monocytes (HPBM) are heterogeneous populations with each subset possesses distinct pathophysiological function in immune system. They can phagocytose microbes or dying cells, present antigens to T cells, or produce effector molecules such as cytokines, myeloperoxidase and superoxide which trigger inflammation response. Such advances have pointed many possibilities of monocyte as therapeutic target for immunological study.

Why choose Human Monocytes from AcceGen?

AcceGen Human monocytes are isolated from the peripheral blood of fully consented healthy donors. The peripheral blood collected through apheresis are processed to obtain mononuclear cells, which are further selected by positive immunomagnetic selection against CD14 to obtain purified monocytes. The monocytes are then cryopreserved immediately to ensure highest viability. Each vial contains more than 1×10^7 cells. All cell lots are not detected with HIV-1, HBV, HCV and other pathogens. Cells should be preserved in Liquid Nitrogen vapor phase upon receive.