Human Microglia
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Microglia are a type of unique myeloid cells, reside in the parenchyma of the healthy central nervous system (CNS), account for 10–15% of all cells found within the brain. Microglia act as the first and main form of active immune defense in the CNS, constantly monitoring the microenvironment, in order to timely respond to different noxious stimuli (effector function). Microglia can express antigens in the context of MHC class II to CD-4 positive T cells.
Microglia Function
Under some circumstances, such as programmed cell death occurs or CNS is injured, microglia will work as brain macrophages to clear tissue debris, damaged cells, or microbes. Besides, microglial cells are also scavenging the CNS for plaques, damaged or unnecessary neurons and synapses, and infectious agents constantly, the processes of which are potentially dangerous. Therefore, microglia are extremely sensitive to pathological changes. These activities are important in the regulation of brain homeostasis during development and in the adult brain, both in physiological and pathology conditions.
Why Choose Human Microglia from AcceGen?
Human Microglia are characterized by immunofluorescence with antibodies to CD11b (Mac-1), CD68, CD86 (B7-2), HLA-ABC, HLA-DR, and RCA-1 lectin.
| Product Code | HM |
| Species | Human |
| Cat.No | ABC-TC3704 |
| Quality Control | All cells test negative for mycoplasma, bacteria, yeast, and fungi. |
| Product Category | Primary Cells |
| Size/Quantity | 1 vial |
| Cell Type | Microglia |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Brain |
| Disease | Normal |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Nervous Cells |
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
For research use only
Human Microglia are a type of myeloid cell that reside in the parenchyma of the healthy central nervous system (CNS), accounting for 10 – 15% of all cells in the brain. They act as the primary active immune defense in the CNS, constantly monitoring the microenvironment and responding to noxious stimuli. Microglia play a crucial role in maintaining brain homeostasis by clearing tissue debris, damaged cells, or microbes, and scavenging for plaques, damaged neurons, and infectious agents.
When programmed cell death occurs or the CNS is injured, microglia act as brain macrophages to clear tissue debris, damaged cells, or microbes. They are highly sensitive to pathological changes and work to regulate brain homeostasis during development and in adult brains, both under physiological and pathological conditions.
Human Microglia from AcceGen are characterized by immunofluorescence with antibodies to several markers, including CD11b (Mac-1), CD68, CD86 (B7-2), HLA-ABC, HLA-DR, and RCA-1 lectin. These markers help in identifying and confirming the presence and purity of microglial cells.
Human Microglia are widely used in research because they play a vital role in the immune defense of the CNS and are involved in clearing debris and pathogens. They are also essential for studying the regulation of brain homeostasis, both during development and in adult brains, under normal and pathological conditions. This makes them valuable for understanding neurological diseases and developing potential treatments.
Researchers choose Human Microglia from AcceGen because these cells are characterized by specific immunofluorescence markers, ensuring high quality and purity. AcceGen provides reliable and well-characterized microglial cells that are essential for accurate and effective research in neuroscience and immunology.
