Human Mast Cells (MCs) – Dermis are specialized immune cells from the dermal layer of human skin. Originating from hematopoietic progenitor cells MCs are found in almost all organs and perform multiple functions in both homeostasis and pathological conditions. They have been implicated in the pathogenesis of diseases, such as Alzheimer’s disease, mastocytosis and related diseases, as well as in the regulation of the epidermal barrier function. MCs are unevenly distributed in the skin, with concentration increasing at sites of inflammation in various pathological conditions, influencing disease progression. Studies have shown that MCs exhibit both inflammatory and anti-inflammatory functions. Mast cells are generally considered to be the cells that cause IgE-mediated allergic reactions. In addition, they also play a role in vascular development and tumorigenesis. They can store and secrete vascular endothelial growth factors including VEGF, CXCL16, DPPIV, endothelin-1, GM-CSF, IL-8, MCP-1, pentraxin 3, serpin E1, etc.
Why choose Human Mast Cells-Dermis from AcceGen?
Human Mast Cells-Dermis from AcceGen are isolated from human skin tissue and maintained under standard culture conditions (37℃, 5% CO2). Each vial contains more than 5×105 cells in 1mL volume. The cells are of high purity and high viability. All cells are negative for mycoplasma, bacteria, yeast, and fungi.
