Human mammary epithelial cells (HMECs) sit within duct and lobes of breast and play an important role in maintaining breast function and facilitate milk production during lactation. Mammary epithelium consists of an inner luminal epithelial cell layer and an outer myoepithelial cell layer adjacent to basement membrane. The luminal lineage can be divided into ductal and alveolar cells while the contractile myoepithelial cells are smooth muscle-like cells found at the basal surface of epithelium. Female breast epithelial cells undergo reorganization during puberty, pregnancy, lactation, and menopause in response to various hormones and cytokine signals, making it susceptible to development of breast cancer.
Why Choose Human Mammary Epithelial Cells, Adult from AcceGen
AcceGen Human mammary epithelial cells are isolated from adult female breast tissue. Cells are cryopreserved at passage 5 and delivered on dry ice. Each vial contains at least 5×10^5 cells in 1 ml volume. Human mammary epithelial cells are negative for mycoplasma, bacteria, yeast, and fungi. HIV-1, Hepatitis B and Hepatitis C are not detected for all donors and/or cell lots Cells are characterized with positive luminal and myoepithelial markers such as cytokeratin 18 and E-cadherin. Mammary epithelial cells are guaranteed to further expand for 15 population doublings with stable activity following AcceGen recommended protocol and culture media.
Immortalized Human Mammary Epithelial Cell Line – hTert and Immortalized Human Mammary Epithelial Cell Line – SV40 are also available in AcceGen.
