AcceGen’s Human Lung Interstitial Macrophages are derived from the lung interstitium, representing a vital component of the second line of defense against microbial invaders due to their phagocytic nature. This heterogeneous population, including macrophages from various sources like bone marrow-derived and embryonic progenitor cells, plays a crucial role in regulating tissue fibrosis, inflammation, and antigen presentation. At steady state, human lung interstitial macrophages express the immunosuppressive cytokine IL-10, contributing to immune balance. Notably, these macrophages exhibit elevated turnover rates, akin to blood monocytes, and display increased TUNEL staining, indicative of a continuous transition with blood monocytes replacing apoptotic interstitial macrophages.
Why choose Human Lung Interstitial Macrophages from AcceGen?
AcceGen’s Human Lung Interstitial Macrophages is recommended for outstanding viability and quality. Verified sterility, such as confirmed mycoplasma negativity through PCR-analysis, and rigorous daily visual checks for the absence of bacteria and fungi, ensure a reliable research foundation.
