Human Lung Fibroblasts (HLF), or Pulmonary Fibroblasts, constitutes main portion of lung interstitium. They play an important role in maintaining lung homeostasis and ventilation. HLF mainly responsible for extracellular matrix (ECM) synthesis and remodeling. Pulmonary fibroblasts display spindle-shaped morphology and characteristic long branching process and gap junction. They are the central mediator of cellular migration and differentiation in wound healing upon injury and chronic inflammation. Abnormal lung fibroblast growth and ECM accumulation are associated with fibrotic disease such as hypoxia-induced pulmonary hypertension and idiopathic pulmonary fibrosis (IPF). The essential role of fibroblast cells in lung fibrosis makes it ideal therapeutic and pathological target.
AcceGen also offers purified Diseased Human Lung Fibroblasts, Idiopathic Pulmonary Fibrosis for research purpose.
Why choose Human Lung Fibroblasts from AcceGen?
Human Lung Fibroblasts from AcceGen are isolated from normal human lung parenchyma. They are cryopreserved at first passage and delivered in dry ice. Each vial contains >5×10^5 cells in 1 ml volume. AcceGen HLF are quality tested to guarantee further expand for 15 population doublings following AcceGen recommended protocol. Cells are negative for von Willebrand Factor, cytokeratins 18 and 19, and alpha-smooth muscle actin by immunocytochemistry staining.
