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Human Lung Adenocarcinoma Carcinoma Associated Fibroblasts | ||||
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| Product Name | Human Lung Adenocarcinoma Carcinoma Associated Fibroblasts | |||
| Price | Get Quote | |||
| Cat.No | ABC-TC5539 | Species | Human | |
| Size/Quantity | 1 vial | |||
| Shipping Info | Dry ice | Storage | Liquid Nitrogen | |
| Description | Human Lung Adenocarcinoma Cancer-Associated Fibroblasts (CAFs) are specialized cells isolated from human lung tumor tissue. CAFs play a significant role in the tumor microenvironment and have been implicated in various aspects of solid tumor biology, including neoplastic progression, tumor growth, angiogenesis, and metastasis.
These fibroblasts are specifically associated with lung adenocarcinoma, a type of non-small cell lung cancer that originates in the peripheral lung tissues. The term “cancer-associated fibroblasts” refers to fibroblastic cells found in the tumor stroma that interact with cancer cells and contribute to the complex dynamics of tumor development.
Why choose Human Lung Adenocarcinoma Carcinoma Associated Fibroblasts from AcceGen? Introducing our meticulously crafted product, manufactured, tested, and validated in an ISO 9001/ISO13485/CLIA certified facility, ensuring the highest standards of quality and safety. Our commitment to excellence is demonstrated through a rigorous set of quality control (QC) tests performed on each batch:
Sterility We conduct comprehensive tests to ensure a negative result for contamination, covering bacterial, fungal, and Mycoplasma (PCR). Additionally, our product is confirmed negative for human pathogens, meeting the stringent requirements for purity.
Viability Post-thaw viability is a crucial aspect of cell functionality. Our product consistently achieves a viability rate of over 95%, ensuring the cells’ robustness and effectiveness in various applications.
Identity Utilizing Short Tandem Repeat (STR) analysis, we verify the identity of our product with precision. This involves checking 16 probes, including 15 STR loci and Amelogenin, guaranteeing the authenticity and uniqueness of the cell line.
Growth We assess the growth characteristics through detailed examinations of morphology and immunocytochemistry involving multiple undifferentiation markers. This ensures the reliability and stability of the cell line throughout its life cycle. | |||
| Disease | Lung Adenocarcinoma Carcinoma | |||
| Source Organ | Lung | |||
| Recommended Medium And Supplement | ABM-TM5539 Human Lung Adenocarcinoma Carcinoma Associated Fibroblasts Medium Kit | |||
| Citation Guide | When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID). | |||
| Application | FOR RESEARCH USE ONLY
The Human Lung Adenocarcinoma Cancer-Associated Fibroblasts (CAFs) offer a versatile platform for a range of research applications. Key applications include:
Cell-Cell Interaction Studies Human Lung Adenocarcinoma CAFs are suitable for exploring cell-cell interactions, providing valuable insights into the dynamic processes within the tumor microenvironment.
Adhesion Assays Researchers can use these cells to investigate adhesion mechanisms, contributing to a better understanding of cancer cell behavior and potential therapeutic targets.
PCR (Polymerase Chain Reaction) The cells are amenable to PCR analysis, enabling the study of specific gene expression patterns or molecular changes associated with lung adenocarcinoma.
Western Blotting Human Lung Adenocarcinoma CAFs serve as a reliable source for protein analysis through Western blotting, aiding in the identification and quantification of specific proteins.
Immunoprecipitation The cells can be utilized for immunoprecipitation studies, allowing researchers to isolate and analyze specific proteins or protein complexes.
Immunofluorescent Flow Cytometry These CAFs are suitable for immunofluorescent flow cytometry, enabling the assessment of cell surface markers and intracellular proteins, providing a deeper understanding of cellular characteristics.
Cell Derivative Generation Researchers can generate cell derivatives from these CAFs for customized research applications, expanding the versatility of the cell line.
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| Growth Conditions | 37 ℃, 5% CO2 | |||
| Cell Type | Fibroblast | |||
| Growth Mode | Adherent | |||
| Product Type | Human Primary Carcinoma Associated Fibroblasts | |||
| Product Image |  | |||
Frequently Asked Questions
What are Human Lung Adenocarcinoma Carcinoma Associated Fibroblasts (CAFs)?
Human Lung Adenocarcinoma Carcinoma Associated Fibroblasts (CAFs) are a type of fibroblast found in the tumor microenvironment of lung adenocarcinoma. They play a significant role in supporting tumor growth, invasion, and metastasis by interacting with cancer cells and modifying the extracellular matrix.
How are Human Lung Adenocarcinoma Carcinoma Associated Fibroblasts different?
Human Lung Adenocarcinoma Carcinoma Associated Fibroblasts (CAFs) differ from normal fibroblasts in that they are activated and often exhibit altered gene expression, enhanced secretion of growth factors, cytokines, and proteases. These changes enable them to support tumor progression, whereas normal fibroblasts typically function in tissue repair and maintenance.
What role do Human Lung Adenocarcinoma Carcinoma Associated Fibroblasts play?
In lung adenocarcinoma, Human Lung Adenocarcinoma Carcinoma Associated Fibroblasts contribute to tumor growth and metastasis by promoting angiogenesis, suppressing immune responses, remodeling the extracellular matrix, and facilitating cancer cell invasion and migration. They are key players in creating a tumor-promoting environment.
How are Human Lung Adenocarcinoma Carcinoma Associated Fibroblasts identified?
Human Lung Adenocarcinoma Carcinoma Associated Fibroblasts are identified by their expression of specific markers such as alpha-smooth muscle actin (α-SMA), fibroblast activation protein (FAP), and platelet-derived growth factor receptor (PDGFR). These markers help distinguish them from normal fibroblasts and other cell types in the tumor microenvironment.
Can Human Lung Adenocarcinoma Carcinoma Associated Fibroblasts be targeted for cancer therapy?
Yes, targeting Human Lung Adenocarcinoma Carcinoma Associated Fibroblasts is an emerging strategy in cancer therapy. Since CAFs play a crucial role in supporting tumor growth and resistance to therapy, disrupting their function or altering their interactions with cancer cells could enhance the effectiveness of existing treatments and reduce tumor progression.
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