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Human Lung Adenocarcinoma Carcinoma Associated Fibroblasts

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Carcinoma-associated fibroblasts (CAFs) have recently been implicated in important aspects of epithelial solid tumor biology such as neoplastic progression, tumor growth, angiogenesis, and metastasis. Immunophenotypes of CAFs are different from Adenocarcinomas in Lung Cancer. These CAFs have therefore have separate and important prognostic value.Product is manufactured, tested and validated in an ISO 9001/ISO13485/CLIA certified facility.
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Home | Primary Cells | Human Primary Cells | Respiratory System Primary Cells | Human Lung Adenocarcinoma Carcinoma Associated Fibroblasts
Species

Human
Cat.No

ABC-TC5539
Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Fibroblast
Shipping Info

Dry ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Lung
Disease

Lung Adenocarcinoma Carcinoma
Storage

Liquid Nitrogen
Product Type

Human Primary Carcinoma Associated Fibroblasts

Description

Human Lung Adenocarcinoma Carcinoma Associated Fibroblasts
Human Lung Adenocarcinoma Cancer-Associated Fibroblasts (CAFs) are derived from human lung tumor tissue. After primary culture, these cells are cryopreserved. CAFs are involved in studying tumor progression, tumor growth, angiogenesis, and metastasis. Studies have shown that these fibroblasts are specifically related to lung adenocarcinoma, a type of non-small cell lung cancer originating in the peripheral lung tissue. These cells should be avoided repeated freezing and thawing during the culture process.

AcceGen Frozen Cells & Cell Lines 1 vial
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Citation

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Application

  • Fibroblasts (CAFs) provide a versatile platform for diverse research applications, including: exploring cell-cell interactions within the tumor microenvironment; conducting adhesion assays to understand cancer cell behavior; performing PCR analysis for gene expression studies; utilizing Western blotting for protein identification/quantification; implementing immunoprecipitation for protein complex isolation; applying immunofluorescent flow cytometry to assess cellular markers; and generating cell derivatives for customized research needs.

Frequently Asked Questions

  • What are Human Lung Adenocarcinoma Carcinoma Associated Fibroblasts (CAFs)?

    Human Lung Adenocarcinoma Carcinoma Associated Fibroblasts (CAFs) are a type of fibroblast found in the tumor microenvironment of lung adenocarcinoma. They play a significant role in supporting tumor growth, invasion, and metastasis by interacting with cancer cells and modifying the extracellular matrix.

  • How are Human Lung Adenocarcinoma Carcinoma Associated Fibroblasts different?

    Human Lung Adenocarcinoma Carcinoma Associated Fibroblasts (CAFs) differ from normal fibroblasts in that they are activated and often exhibit altered gene expression, enhanced secretion of growth factors, cytokines, and proteases. These changes enable them to support tumor progression, whereas normal fibroblasts typically function in tissue repair and maintenance.

  • What role do Human Lung Adenocarcinoma Carcinoma Associated Fibroblasts play?

    In lung adenocarcinoma, Human Lung Adenocarcinoma Carcinoma Associated Fibroblasts contribute to tumor growth and metastasis by promoting angiogenesis, suppressing immune responses, remodeling the extracellular matrix, and facilitating cancer cell invasion and migration. They are key players in creating a tumor-promoting environment.

  • How are Human Lung Adenocarcinoma Carcinoma Associated Fibroblasts identified?

    Human Lung Adenocarcinoma Carcinoma Associated Fibroblasts are identified by their expression of specific markers such as alpha-smooth muscle actin (α-SMA), fibroblast activation protein (FAP), and platelet-derived growth factor receptor (PDGFR). These markers help distinguish them from normal fibroblasts and other cell types in the tumor microenvironment.

  • Can Human Lung Adenocarcinoma Carcinoma Associated Fibroblasts be targeted for cancer therapy?

    Yes, targeting Human Lung Adenocarcinoma Carcinoma Associated Fibroblasts is an emerging strategy in cancer therapy. Since CAFs play a crucial role in supporting tumor growth and resistance to therapy, disrupting their function or altering their interactions with cancer cells could enhance the effectiveness of existing treatments and reduce tumor progression.

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