Human Liver Sinusoidal Endothelial Cells (HLSECs) are the most abundant non-parenchymal hepatic cells (about 60%), strategically placed lining the hepatic sinusoid, and therefore become the first contact of tissue with circulating lymphocytes. Apart from forming a barrier within the hepatic sinusoids, more physiological and immunological functions of HLSECs have been discovered.
Liver Sinusoidal Endothelial Cells Function
The functions like filtration, endocytosis, antigen presentation and leukocyte recruitment. Compared to other capillary endothelial cells, liver sinusoidal cells exhibit unique structural and functional features – work as dendritic cells and present antigen for CD4+ T cells. The HLSEC maintain immune homeostasis within the liver, implicated in liver regeneration and mediate the immune response with acute and chronic liver injury.
Why Choose Human Liver Sinusoidal Endothelial Cells from AcceGen?
AcceGen cryopreserves primary human liver sinusoidal endothelial cells immediately after purification and delivered frozen. Each vial contains about 5 x 10^5 cells in 1 ml. AcceGen HLSECs are characterized by immunofluorescence with antibodies specific to vWF/Factor VIII and CD31 (PECAM).
