Human Leydig Cells
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Human Leydig Cells (HLC) are located in the testes of the male gonads, between seminiferous tubules. They have round vesicular nuclei and a granular eosinophilic cytoplasm and play an important role in maintaining spermatogenesis and controlling hormone regulation. They are responsible for the production of testosterone and are the main source of male androgens. Leydig cells have the large and well-developed smooth endoplasmic reticulum, large and numerous lipid droplets, and numerous mitochondria with tubular cristae. They also contain lipofuscin. The well-developed smooth endoplasmic reticulum and rich lipid content are the characteristics of of Leydig cells that produce androgens more efficiently. The production process of androgens is regulated by many factors, mainly luteinizing hormone (LH). Leydig cell markers include 3 beta-hydroxysteroid dehydrogenase (3b-HSD), 7-dehydrocholesterol reductase (7-DHCR), Calretinin, Cyp17 and Cyp11a1, etc.
Why choose Human Leydig Cells from AcceGen?
AcceGen’s Human Leydig Cells (HLC) is derived from human testis. They are cryopreserved at passage one and delivered frozen. Each vial contains more than 0.5 million cells. These cells have high viability (typically > 70%). They are negative for mycoplasma, bacteria, yeast and fungi.
| Species | Human |
| Cat.No | ABC-H0060X |
| Quality Control | All cells test negative for mycoplasma, bacteria, yeast, and fungi. |
| Product Category | Primary Cells |
| Size/Quantity | 1 vial |
| Cell Type | Leydig Cell |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Disease | Normal |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Male Reproductive Cells |
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
FOR RESEARCH USE ONLY
Leydig cells can be used in researches on treatment for diseases that lead to low serum testosterone levels. They can also be used to study the mechanisms of testosterone formation. In men, reduced testosterone production can significant impact metabolism and quality of life. With the understanding of the mechanisms of testosterone formation, it is possible to increase serum testosterone by stimulating the Leydig cells themselves using pharmacological approaches.
