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Species | Human |
Cat.No | ABC-H0060X |
Quality Control | All cells test negative for mycoplasma, bacteria, yeast, and fungi. |
Product Category | Primary Cells |
Size/Quantity | 1 vial |
Cell Type | Leydig Cell |
Shipping Info | Dry Ice |
Growth Conditions | 37 ℃, 5% CO2 |
Disease | Normal |
Biosafety Level | 1 |
Storage | Liquid Nitrogen |
Product Type | Male Reproductive Cells |
Human Leydig Cells (HLC) are derived from the testicular tissue of the male gonads, and located in the interstitium of the testis near the seminiferous tubules. After primary culture, these cells are cryopreserved. Human Leydig Cells (HLC) have the function of producing testosterone. Studies have shown that Human Leydig Cells (HLC) are relevant to the maintenance of spermatogenesis and the regulation of hormones. Stromal cell markers include 3β-hydroxysteroid dehydrogenase (3β-HSD), 7-dehydrocholesterol reductase (7-DHCR), Calretinin, Cyp17, Cyp11a1, and others. During culture, repeated freezing and thawing should be avoided.
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Leydig cells are essential for research into diseases that lead to low serum testosterone levels. They can also be used to study the mechanisms of testosterone formation. In men, reduced testosterone production significantly impacts metabolism and quality of life. Understanding the mechanisms behind testosterone formation can help stimulate Leydig cells using pharmacological approaches to increase serum testosterone levels.