Human LAG-3 (Luc) Jurkat Reporter Cell
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The Human LAG-3 (Luc) Jurkat Reporter Cell was engineered to not only express the NFAT response element driving luciferase expressing systems, but also express the receptor full length human LAG-3 (Gene ID: 3902), which can use to evaluate the potency of LAG-3 blockade. When co-cultured with target cells expressing human MHCⅡ, the LAG-3/MHCⅡ interaction inhibits TCR signaling and NFAT-mediated luminescence. Blocking the LAG-3/MHCⅡ interaction by anti-LAG-3 antibodies releases the inhibitory signals and results in TCR activation and NFAT-mediated luminescence.
Species | Human |
Cat.No | ABC-RC178F |
Quality Control | All cells test negative for mycoplasma, bacteria, yeast, and fungi. |
Product Category | Transfected Stable Cell Lines |
Size/Quantity | 1 vial |
Cell Type | T Lymphoblast |
Shipping Info | Dry Ice |
Growth Conditions | 37 ℃, 5% CO2 |
Source Organ | Blood |
Disease | Acute T Cell Leukemia |
Biosafety Level | 1 |
Storage | Liquid Nitrogen |
Product Type | Reporter Stable Cell Lines |
Host Cell | Jurkat |
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
For research use only