Discover top-quality products tailored for scientific and medical research. Request a personalized quote today
to enhance your projects.
| Species | Human |
| Cat.No | ABC-TC4369 |
| Quality Control | All cells test negative for mycoplasma, bacteria, yeast, and fungi. |
| Product Category | Primary Cells |
| Size/Quantity | 1 vial |
| Cell Type | Kupffer Cell |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Liver |
| Disease | Normal |
| Storage | Liquid Nitrogen |
| Product Type | Hepatic Cells |
| Key Features | Backed by AcceGen advanced technology |
Isolated and enriched from dissociated human liver tissue, Human Kupffer cells (HKC) are the resident macrophages in human liver. Kupffer cells are the densest innate liver immune cells and the first line of defense against bacteria and toxins in the intestine. Liver Kupffer cells have typical macrophages abilities like modulating hepatic inflammation and injury. Activated hepatic Kupffer cells could release inflammatory cytokines, growth factors and reactive oxygen species.
In vivo, the activation of Kupffer cells could mediate inflammation that develop into liver diseases such as Non-Alcoholic Fatty Liver Disease (NAFLD), Non-Alcoholic Steatohepatitis (NASH), and liver damage associated with certain bioactivated chemicals.
Why Choose Human Kupffer Cells from AcceGen?
AcceGen cryopreserves our Human Kupffer Cells for about 5 x 10^5 cells/vial after isolation, without being cultured.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
For research use only
Kupffer cells are specialized macrophages located in the liver. They are part of the mononuclear phagocyte system and play a critical role in the body’s immune response by clearing pathogens, debris, and aged red blood cells from the blood.
The primary function of Kupffer cells is to act as scavengers in the liver, engulfing and digesting cellular debris, pathogens, and other particles through phagocytosis. They also produce cytokines and other molecules that modulate immune responses and inflammation.
Kupffer cells are typically isolated from liver tissue through a process that involves enzymatic digestion of the liver, followed by density gradient centrifugation or magnetic sorting to separate them from other liver cell types.
Kupffer cells contribute to liver homeostasis by clearing pathogens and debris, regulating immune responses, and producing cytokines that maintain the balance of liver cell functions. They also play a role in the metabolism of lipids and iron.
Kupffer cells interact with hepatocytes, stellate cells, endothelial cells, and infiltrating immune cells through direct cell-to-cell contact and the secretion of signaling molecules. These interactions help coordinate immune responses and maintain liver function.
