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Human Keratinocytes, Adult

  • BSL

    1

  • 260
AcceGen epidermal keratinocytes are available from adult and neonatal donor tissue and are provided at the earliest passage without the use of a murine feeder layer. Keratinocytes are available from donors of varying ages, genders, and diabetes status. Donor matched epidermal keratinocytes, dermal fibroblasts, melanocytes and subcutaneous preadipocytes are available.
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Home | Primary Cells | Human Primary Cells | Others | Human Keratinocytes, Adult
Species

Human
Cat.No

ABC-TC3030
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Others
Size/Quantity

1 vial
Cell Type

Keratinocyte
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Keratinocyte

Description

Keratinocytes are the major cells to Human Keratinocytes, AdultHuman Keratinocytes, Adult are primary cells derived from adult human epidermis, specifically from the basal layer of the skin. These cells play a critical role in forming the epidermal barrier and protecting against mechanical, chemical, and microbial damage. They are used in studies of skin disorders such as psoriasis, squamous cell carcinoma, and wound healing. Keratinocytes differentiate into basal, spinous, granular, and cornified layers and exhibit small, polygonal morphology with a high nuclear-cytoplasmic ratio, becoming flatter during differentiation. Cells are typically used at early passage to ensure high viability. Karyotype analysis shows a normal diploid chromosomal set in early passages. These cells express keratinocyte-specific markers, including KRT5, KRT14 (basal), and KRT1, KRT10, and involucrin.

AcceGen Frozen Cells & Cell Lines 1 vial
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Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Application

  • Human keratinocytes are widely used in scientific applications.. In would healing and some pathogenic conditions, growth factors and cytokines like IL-1, TNF-α, TGF-α, TGF-β, and IFN-γ affect keratinocyte activation. Keratinocytes respond to signals from fibroblasts, such as TGF-β, by expressing K5 and K14, which leads to the restoration of their healthy basal phenotype. The differentiation of keratinocytes is mediated through the involvement of the mitogen-activated protein kinase (MAPK) pathway, which is influenced by factors such as epidermal growth factor (EGF), TNF, and calcium influx. Keratinocytes are also involved in the immune signaling pathway, as they express Toll-like receptors (TLRs) that respond to pathogen-associated molecular patterns (PAMPs). Toll-like receptors are expressed in human keratinocytes.TLR3, 4, 5 ligand stimulation can trigger an immune response in keratinocytes..

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