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| Product Code | HH |
| Species | Human |
| Cat.No | ABC-TC3646 |
| Quality Control | All cells test negative for mycoplasma, bacteria, yeast, and fungi. |
| Product Category | Primary Cells |
| Size/Quantity | 1 vial |
| Cell Type | Hepatocyte |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Liver |
| Disease | Normal |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Hepatic Cells |
| Key Features | -Backed by AcceGen advanced technology -Ship cryopreserved cells in dry ice -Quality-tested for accurate results |
Human Hepatocytes (HH) are hepatic cells isolated from the whole human liver, making up 80% of the liver’s mass. Liver hepatocytes are multifunctional. Hepatocyte involves in the production and synthesis of functional proteins that participate in energy metabolism, biotransformation, detoxification, etc. Hepatocytes secrete many materials including structural protein and intracellular enzymes, cholesterol, bile, detoxify substances. Understanding the molecular mechanisms of the liver is beneficial to elucidate new therapies for treatment of hepatic disease.
Primary hepatocyte cultures are unable to expand, which is challenging for long-term research on understanding the regulation of human hepatocytes.
Why Choose Human Hepatocytes from AcceGen?
AcceGen cryopreserves our Human Hepatocytes for about 1 x 10^6 cells/mL, characterized by immunofluorescence with specific antibodies against albumin, cytokeratin-18 and vimentin.
Expanding or long-term culturing is not recommended, as the cells do not proliferate in culture.
Immortalized Human Hepatocytes are also available in AcceGen.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
For research use only
Applications of Human Hepatocytes
Constitute a more predictive model for pharmaceutical research
Drug metabolism study, including clearance, hepatotoxicity, drug-drug interactions
CYP enzymes expression or inhibition studies
3D co-culture
Human Hepatocytes are the main functional cells of the liver, responsible for various metabolic processes, detoxification, and protein synthesis. They are isolated from donor’s liver tissue through enzymatic digestion and are either freshly isolated or cryopreserved for research use.
Human Hepatocytes are widely used in drug metabolism studies, toxicology testing, liver disease research, pharmacokinetic studies, and tissue engineering. They serve as a critical model for understanding liver function and drug interactions.
Human Hepatocytes are primary cells with normal liver cell functions, making them more physiologically relevant for certain studies. In contrast, hepatoma cell lines, such as HepG2, are cancer-derived and may not accurately represent normal liver function, particularly in drug metabolism and toxicity studies.
No, Human Hepatocytes cannot be passaged in culture like immortalized cell lines. They are primary cells, meaning they have a limited lifespan and do not proliferate in culture. After a few days in culture, hepatocytes will begin to lose their specific liver functions and eventually undergo senescence. For extended studies, it is often necessary to use fresh or cryopreserved hepatocytes for each experiment rather than attempting to passage them.
We offer both suspension and Platable Human Hepatocytes in various formats and quantities. Please contact our sales team for detailed information on the specific options available.
