Human Fibroblast-Like Synoviocytes (HFLS), also known as synovial fibroblasts, are the predominant cell types consisting of synovial intima. Two major cell populations of synoviocytes, macrophage-like (type A) synoviocytes and fibroblast-like (type B) synoviocytes, have been identified. Abnormal fibroblast-like synoviocytes (FLS) activity is closely associated with the occurrence and progression of rheumatoid arthritis (RA), a chronic disorder marked by inflammation in the synovium. Rheumatoid arthritis FLS exhibit aggressive phenotypes and produce cytokines and proteases that perpetuate inflammation and eventually contribute to cartilage destruction. Research and therapeutic strategies targeting FLS could provide novel insight into RA diagnosis and treatment.
Why choose HFLS-RA from AcceGen?
HFLS-RA is isolated from adult joint synovial tissue with RA using AcceGen’s advanced technology. Cells at second passage are cryopreserved to ensure the best viability. Each vial contains more than 5×10^5 cells in 1ml volume. HFLS-RA is characterized by fibroblast-like morphology and the expression of fibronectin using immunofluorescence. HFLS-RA is guaranteed for further expansion of at least 5 doublings following protocols provided by AcceGen.
