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Human Fibroblast-Like Synoviocyte Osteo Arthritis, Adult

  • BSL
  • 72
Human Fibroblast-Like Synoviocytes (HFLS) are isolated from synovial tissues obtained from patients with Rheumatoid Arthritis (RA) / Osteoarthritis (OA). They are cryopreserved at second passage and can be cultured and propagated at least 5 population doubling.
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Home | Primary Cells | Human Primary Cells | Motion System Primary Cells | Human Fibroblast-Like Synoviocyte Osteo Arthritis, Adult

Human Fibroblast-Like Synoviocytes (Osteoarthritis, Adult), are isolated from the synovial tissue of donors with osteoarthritis. Human fibroblast-like synoviocytes (FLS), also known as synovial fibroblasts, are vital constituents of the synovial membrane lining the inner layer of joint capsules. These cells play a pivotal role in maintaining normal joint function by generating extracellular matrix components and lubricants. However, in conditions like rheumatoid arthritis (RA), FLS can undergo proliferation and phenotypical alterations, transforming into key contributors to inflammation persistence through their direct and indirect destructive actions, thus exacerbating joint damage and dysfunction.

 

Why choose Human Fibroblast-Like Synoviocyte-Osteoarthritis, Adult from AcceGen?

The Human Fibroblast-Like Synoviocyte-Osteoarthritis, Adult cells from AcceGen are cryopreserved at the 2nd passage, with each vial containing more than 0.5×106 cells. These cells have the capacity to undergo at least 5 doublings in culture and are provided in a sterile state, free from bacteria, yeast, fungi, mycoplasma, and viruses, ensuring their suitability for research and experimentation.

Product Code

HFLS
Species

Human
Cat.No

ABC-TC3620
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Fibroblast-Like
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

synovium
Disease

Normal
Storage

Liquid Nitrogen
Product Type

Synoviocytes

Citation

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Application

  • FOR RESEARCH USE ONLY

  • Human Fibroblast-Like Synoviocyte-Osteoarthritis, Adult, referred to as HFLS-OA, serve as valuable tools in diverse research applications. They are instrumental in probing synoviocyte physiology, shedding light on their role in both the development and treatment of osteoarthritis. HFLS-OA cells are utilized to investigate various aspects such as phenotype, proinflammatory mediator production, signaling pathways, cell proliferation, and chemotaxis. Moreover, when combined with normal FLS (HFLS)  and rheumatoid arthritis-FLS (HFLS-RA) , they aid in studying interleukin production, evaluating potential anti-inflammatory and antirheumatic compounds, as well as assessing the production of erosive enzymes, providing critical insights into the complexities of osteoarthritis and potential therapeutic avenues.

Frequently Asked Questions

  • What are Human Fibroblast-Like Synoviocytes?

    Human Fibroblast-Like Synoviocytes (FLS) are specialized cells derived from the synovial membrane of joints. They play a vital role in maintaining the integrity of the synovial fluid and joint function. FLS are involved in producing and remodeling the extracellular matrix of the synovial tissue and secreting lubricating synovial fluid components.

  • Application of Human Fibroblast-Like Synoviocytes in Osteoarthritis Research

    Human Fibroblast-Like Synoviocytes (FLS) are vital in osteoarthritis research, helping to understand disease mechanisms, screen therapeutic agents, discover biomarkers, and analyze gene expression. They provide an in vitro model of the joint microenvironment, facilitating studies on cell interactions and the impact of synovial changes on OA pathology.

  • How do I culture Human Fibroblast-Like Synoviocyte Osteo Arthritis?

    To culture Human Fibroblast-Like Synoviocytes (FLS) from osteoarthritis patients, isolate synovial tissue, enzymatically dissociate cells, and culture in DMEM supplemented with 10% FBS, 1% penicillin-streptomycin, and 1% glutamine. Maintain cells at 37°C with 5% CO2, changing medium every 2-3 days. Passage cells at 70-80% confluency.

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Tags

  • Human (1729)
  • Normal (1578)
  • Synoviocyte (7)
  • Synoviocytes (7)

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