Human Fibroblast-Like Synoviocytes (HFLS) are primary fibroblast-like synoviocytes (FLS) isolated from normal human synovial membrane tissue. FLSs are type B synovial cells, and type A synovial cells are macrophage-like synovial cells. The function of FLS is to produce hyaluronan and other extracellular components in the synovial fluid to maintain the physiological functions of the synovial membrane. Synovial membrane plays an indispensable role in the mechanical movement of joints, and FLS plays an essential role in maintaining the stability of synovial structure and function. FLS shows several aggressive pathological changes and directly changes the synovial microenvironment, which is related to several joint diseases, such as synovial tumors and arthritis, especially rheumatoid arthritis (RA).
Why choose Adult HFLS of Normal Tissue from AcceGen?
AcceGen cryopreserves our HFLSs in the second passage for the best viability and plating efficiency. Adult primary HFLS of Normal Tissue provided by AcceGen can be cultured and propagated at least 5 population doublings.
