Human Dendritic Cells

Human dendritic cells (DC) are specialized antigen-presenting cells that play a crucial role in initiating and regulating immune responses. They have the unique ability to activate naïve T cells and promote their differentiation into effector cells. Additionally, they are involved in maintaining immune tolerance under normal physiological conditions. Human DCs can be distinguished by their high expression of major histocompatibility complex class II molecules (MHC-II) and CD11c. To ensure detailed characterization, these cells are tested for specific surface markers, including CD11c⁺, CD86⁺, CD80⁺, HLADR⁺, and CD14^–. In culture, human DCs can survive for up to 7 days as immature dendritic cells (iDCs) when exposed to appropriate cytokines like IL-4 and GM-CSF. Moreover, these cells can be differentiated into mature dendritic cells by the addition of TNF-α and IL-1β.

Why choose Human Dendritic Cells from AcceGen?

Choosing human dendritic cells from AcceGen offers several advantages. Our cryopreserved human dendritic cells guarantee a high cell count of ≥3 million viable cells per ampoule. The expression levels of key markers such as CD80, CD86, HLA-DR, CD11c, and CD14 are tested. Importantly, the cells are screened for the absence of HIV-1, hepatitis B, and hepatitis C in all donors and/or cell lots. A Certificate of Analysis can be provided for each purchased cell lot, ensuring quality and traceability.