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Human Colonic Epithelial Cells | ||||
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| Product Name | Human Colonic Epithelial Cells | |||
| Price | Get Quote | |||
| Product Code | HCoEpiC | |||
| Cat.No | ABC-TC3570 | Species | Human | |
| Size/Quantity | 1 vial | Biosafety Level | 1 | |
| Shipping Info | Dry Ice | Storage | Liquid Nitrogen | |
| Description | Colonic epithelium cover the colonic mucosal surface and maintain the gut homeostasis by harboring the commensal bacteria in the outer mucus layer. Most colonic epithelial cells are absorptive colonocytes distributed in the crypt top, composed of specilised lineages including secretory goblet and enteroendocrine cells (EECs). They not only coordinate gut absorptive and secretory process, but also control mucosal immunity by presenting antigens to T cells. Dysregulation of the colonic homeostasis is often associated with intestinal inflammation, which underpins various intestinal disorders including bacterial infection, inflammatory bowel disease (IBD) and colonic cancer. | |||
| Disease | Normal | |||
| Source Organ | Colonic | |||
| Quality Control | All cells test negative for mycoplasma, bacteria, yeast, and fungi. | |||
| Recommended Medium And Supplement | ABM-TM3570 Human Colonic Epithelial Cells Medium Kit | |||
| Citation Guide | When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID). | |||
| Application | For research use only | |||
| Key Features | -Backed by AcceGen advanced technology | |||
| Growth Conditions | 37 ℃, 5% CO2 | |||
| Cell Type | Epithelial | |||
| Growth Mode | Adherent | |||
| Product Type | Intestinal Cells | |||
| Product Image |  | |||
Frequently Asked Questions
What are Human Colonic Epithelial Cells?
Human Colonic Epithelial Cells are cells that line the inner surface of the colon. They are essential for absorbing water and electrolytes, producing mucus, and forming a barrier against pathogens and toxins.
How many times can Human Colonic Epithelial Cells be passaged?
Human Colonic Epithelial Cells can typically be passaged 3-5 times. However, with each passage, their epithelial characteristics may weaken. Therefore, it is generally recommended to use these cells within three passages to ensure their functionality and reliability in experiments.
What are the differences between Human Colonic Epithelial Cells and human intestinal epithelial cells?
Functionally, Human Colonic Epithelial Cells are specialized for absorbing water and electrolytes, producing mucus, and maintaining colonic health, whereas human intestinal epithelial cells focus more on nutrient absorption and interaction with gut microbiota.
How are Human Colonic Epithelial Cells used in drug development and testing?
Human Colonic Epithelial Cells are utilized in drug development to study drug absorption, metabolism, and toxicity specific to the colonic environment. They help researchers understand how drugs interact with colonic epithelial cells and assess their effectiveness and safety in treating colonic diseases such as ulcerative colitis and colorectal cancer.
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