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Human Choroid Plexus Epithelial Cells

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The choroid plexus epithelial cells (CPEpiC) are the structural basis, form a selective barrier between the nervous system and the blood, and secrete cerebrospinal fluid into the ventricles of the brain. CPEpiC express inward-rectifying anion channels which are thought to have an important role in the secretion of cerebrospinal fluid. CPEpiC synthesize and secrete many […]
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Home | Primary Cells | Human Primary Cells | Nervous System Primary Cells | Human Choroid Plexus Epithelial Cells
Product Code

HCPEpiC
Species

Human
Cat.No

ABC-TC3568
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Epithelial
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Choroid Plexus
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Nervous Cells
Key Features

-Backed by AcceGen advanced technology
-Cryopreserved for highest viability and plating efficiency
-Quality-tested for accurate results

Description

In central nervous system, the choroid plexus acts as a barrier that separates the blood from cerebrospinal fluid (CSF). It is composed of cuboidal epithelium surrounding capillaries that embedded in a loose connective tissue. The choroid plexus epithelial cells (CPECs), linked by tight junctions, form a neuroprotective barrier by regulating the exchange of electrocytes, nutrients, metabolic wastes, and xenobiotics into and out of the central nervous system. The choroid plexus epithelium is responsible for synthesis and secretion of CSF, regulation of hormone signaling and passage of leukocytes during brain injury and infections. Morphological changes such as atrophy of choroidal epithelial cells, are commonly seen in aging and neurological disorders such as Alzheimer disease.
Why choose Human Choroid Plexus Epithelial Cells from AcceGen?
Human choroid plexus epithelial cells are derived from human choroid plexus. Cells are cryopreserved immediately after purification and delivered in dry ice. Each vial contains > 5×10^5 cells in 1 ml volume. Choroidal epithelial cells are characterized with antibodies specific to cytokeratin-18, -19 and vimentin. Cells are tested negative for HIV-1, HBV, HCV and other pathogens. Human choroid plexus epithelial cells are quality tested and guaranteed to further expand for 5 population doublings when cultured in AcceGen recommended cell culture media.

AcceGen Frozen Cells & Cell Lines 1 vial
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Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Erb, U., Schwerk, C., Schroten, H., & Karremann, M. (2020). Review of functional in vitro models of the blood-cerebrospinal fluid barrier in leukaemia research. Journal Of Neuroscience Methods, 329, 108478. https://doi.org/10.1016/j.jneumeth.2019.108478

Application

  • For research use only

  • Human choroid plexus epithelial cells provide an excellent model for studying CSF secretion and can be useful in building transepithelial model of the blood-CSF barrier in vitro. They can also be used to study molecular exchange mechanism of the choroid plexus and pathophysiology associated with the dysfunction of CPECs.

Frequently Asked Questions

  • What are Human Choroid Plexus Epithelial Cells?

    Human Choroid Plexus Epithelial Cells are specialized cells found in the choroid plexus, a structure within the brain’s ventricles responsible for producing cerebrospinal fluid (CSF). These cells form a barrier between the blood and CSF, and regulate the composition of CSF by transporting ions and nutrients.

  • What are the primary functions of Human Choroid Plexus Epithelial Cells?

    The main function of these cells is to produce and regulate the composition of cerebrospinal fluid (CSF). They maintain the blood-CSF barrier, transport ions, and remove waste products from the brain, playing a vital role in maintaining the brain’s homeostasis.

  • What role do Human Choroid Plexus Epithelial Cells play in the blood-CSF barrier?

    These cells form tight junctions that create the blood-CSF barrier, which prevents harmful substances in the blood from entering the CSF. They selectively allow the transport of ions, nutrients, and other molecules into the CSF while blocking toxins and pathogens.

  • What are Human Choroid Plexus Epithelial Cells used for in research?

    These cells are used in research related to cerebrospinal fluid production, blood-CSF barrier integrity, neuroinflammation, and brain homeostasis. They are also utilized in drug discovery to develop therapies for diseases that affect the choroid plexus or CSF regulation.

  • Can Human Choroid Plexus Epithelial Cells be used to model neurological diseases?

    Yes, these cells are valuable for modeling neurological diseases, particularly those involving disruptions in CSF production or blood-CSF barrier dysfunction. They are used to study neuroinflammatory diseases, hydrocephalus, and central nervous system infections.

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