Human CD4+/CD25+ Regulatory T Cells (Tregs), formerly known as suppressor T cells, are a subpopulation of T cells. They are derived from progenitor cells in bone marrow and play an important role in maintaining immune homeostasis. Tregs act by immunosuppression or downregulation of other immune cells, preventing autoimmune disease and chronic inflammation. However, its suppressiveness also limits some beneficial immune responses during microorganism infection and anti-tumor activity. Naturally occurring Tregs (nTregs) express CD4, CD25 and a key transcription factor forkhead box P3 (FOXP3). Human CD4+/CD25+ Regulatory T Cells also downregulate the expression of CD127 (or IL-7R), which can be used as Treg cells marker during identification and purification.
Why Choose Human CD4+/CD25+ Regulatory T Cells from AcceGen?
AcceGen Human CD4+/CD25+ Regulatory T Cells were isolated from peripheral blood using positive or negative immunomagnetic selection.
All Treg cells were cryopreserved in cell culture media kit. Each vial contains 1 million cells or can be customized on request.
All donors have passed QC test and been tested negative for HIV, HBV, HCV, mycoplasma, and chlamydia.
We provide our customers with optimal culture protocols, which has been optimized by our technicians and guarantee timely technical support if any questions. Our cell product has high purity, is easily accessible and ready-to-use in scientific research and laboratories.
