Human CD32a (131R) (Luc) Jurkat Reporter Cell
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The Human CD32a (131R) (Luc) Jurkat Reporter Cell was engineered to not only express the NFAT response element driving luciferase expressing systems, but also express the receptor full length human CD32a mutated to an Arginine (R) at amino acid 131 exhibiting a lower affinity for IgG2 isotypes compared to CD32a-131H, which can use to evaluate ADCP activity of antibodies in the presence of corresponding target cells. When co-cultured with a target cell and relevant antibody, the antibody simultaneously binds the target cell antigen and CD32a (131R) receptor on the surface of Human CD32a (131R) (Luc) Jurkat Reporter Cell, resulting in receptor clustering, intracellular signaling and NFAT-mediated luminescence.
Species | Human |
Cat.No | ABC-RC077F |
Quality Control | All cells test negative for mycoplasma, bacteria, yeast, and fungi. |
Product Category | Transfected Stable Cell Lines |
Size/Quantity | 1 vial |
Cell Type | T Lymphoblast |
Shipping Info | Dry Ice |
Growth Conditions | 37 ℃, 5% CO2 |
Source Organ | Blood |
Disease | Acute T Cell Leukemia |
Biosafety Level | 1 |
Storage | Liquid Nitrogen |
Product Type | Reporter Stable Cell Lines |
Host Cell | Jurkat |
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For research use only