Eosinophils are bone marrow-derived granulocytes that represent about 5% of leukocytes in peripheral blood. Activated eosinophils are involved in defense against parasitic, bacterial, and viral infections and play an important role in promoting allergic inflammatory processes, including asthma. Eosinophils are characterized by bilobed nuclei and large specific granules. These cytotoxic granules are composed of four major proteins: eosinophil peroxidase, major basic protein (MBP), eosinophil cationic protein (ECP) and eosinophil-derived neurotoxin (EDN). CD66b, also called CEACAM8, is a highly expressed protein on eosinophils, which regulates the adhesion and activation of eosinophils by interaction with galectin-3 and CD11b.
Why choose Human CD16-/CD66b+ Eosinophils-Negatively Selected from AcceGen?
Human CD16-/CD66b+ eosinophils-negatively selected are isolated from peripheral blood using AcceGen’s negative immunomagnetic separation techniques. Cells are cryopreserved to ensure the best viability. Each vial contains more than 1×10^6 cells in 1ml volume.
