+1 862-686-2696

  • Celebrate the holiday season with AcceGen’s highest discounts of the year. Merry Christmas and Happy New Year!

    Learn More
Featured Products
Primary Cells
Tumor Cell Lines
MicroRNA Agomir/Antagomir
Stem Cells
Immortalized Cell Lines
Transfected Stable Cell Lines
Nucleic Acid Kits
Explore Products
Cell
MicroRNA
Test and Analysis
Primary Cells

Human Cardiac Fibroblasts

  • BSL

    1

  • 115
The cardiac fibroblasts (CF) are the principal cell type of the heart. They provide structural support for cardiac myocytes and are responsible for extracellular matrix synthesis in the heart during growth and pathophysiological conditions. CF are an important cellular component of myocardial responses to injury and the source of paracrine growth factors. Their proliferation and […]
Request Your Custom Quote Today

Discover top-quality products tailored for scientific and medical research. Request a personalized quote today
to enhance your projects.

Get a Quote
  • High Purity Levels
  • Precision and Reliability
  • Customization Options
Home | Primary Cells | Human Primary Cells | Blood System Primary Cells | Human Cardiac Fibroblasts

Human Cardiac Fibroblasts (HCFs) are isolated from heart tissue, providing structural support for cardiac myocytes. HCF is one of the major cellular components in the heart, participating in heart function, homeostasis, and structure. Cardiac fibroblast cells secrete collagen and play a role in providing structural support for the heart. The cardiac fibroblast cell proliferation and synthesis of matrix are vital to scar formation in myocardial infarction and cardiac fibrosis. However, inappropriate cardiac fibroblast proliferation is a causative factor in cardiac fibrosis.
After heart injury, some chemical signals like growth factors, cytokines, and matrikines are secreted in paracrine or autocrine manner. Those factors act on cardiac fibroblasts via changing fibroblast gene expression and boosting cell migration to the injured area, which then promote wound healing and scar formation.

Why Choose HCF from AcceGen?
HCFs are in low passage for the best viability and plating efficiency and able to passage 15 passages under instructions.
Cardiac fibroblast cells are characterized by immunofluorescence with antibody specific to fibronectin.
Fibroblast specific media is optimized for HCF characteristics. Optimized Xeno-free media culturing cardiac fibroblast can be used to establish the model for would healing and other basic cell biology study. Optimized Xeno-free media are also available in AcceGen.

Product Code

HCF
Species

Human
Cat.No

ABC-TC3533
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Fibroblast
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Cardiac Cells

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

View More
AcceGen Frozen Cells & Cell Lines 1 vial
View Product Image

Application

  • For research use only

  • Cardiac fibroblast culture has been widely applied in studying the remodeling of the cardiac matrix by physiological (exercise) and pathological (hypertension) stressors. Cardiac fibroblast model is excellent to study extracellular matrix producing and remodeling, as well as myocardial responses to injury like wounds, toxicology and pathology. Suitable to establish serum-free human feeder layers for human embryonic stem cell cultures.

Frequently Asked Questions

  • What are Human Cardiac Fibroblasts?

    Human Cardiac Fibroblasts are specialized cells found in the connective tissue of the heart. They play a crucial role in maintaining the structural integrity of the heart by producing and remodeling the extracellular matrix, which supports cardiac muscle cells and blood vessels.

  • What are the primary functions of Human Cardiac Fibroblasts?

    The primary functions of these fibroblasts include the synthesis and regulation of the extracellular matrix, which maintains the structure of the heart. They also play a critical role in the repair and remodeling of heart tissue following injury, such as myocardial infarction.

  • What are Human Cardiac Fibroblasts used for in research?

    Human Cardiac Fibroblasts are used in studies related to cardiac repair, fibrosis, heart failure, tissue engineering, and drug development. They are crucial in developing therapies that aim to prevent or reverse fibrosis and other pathological changes in the heart.

  • What factors influence the activation of Human Cardiac Fibroblasts?

    The activation of Human Cardiac Fibroblasts is influenced by factors like mechanical stress, inflammatory cytokines (e.g., TGF-β), and signals from injured cardiac tissue. These factors can lead to fibroblast-to-myofibroblast transformation, which contributes to the excessive production of extracellular matrix and fibrosis.

  • Online Inquiry
  • Product Reviews

Inquiring Human Cardiac Fibroblasts

We know how valuable your research is to you, but are you wondering what you can expect to pay for quick accurate results every time? Fill out a request in the form below and we’ll get back to you within 24 hours with a quote.
High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

Tags

  • Fibroblast (273)
  • Heart (52)
  • Human (1729)
  • Normal (1578)

Let's Advance Life Science Research Together

Contact Us
AcceGen Scroll Top Button