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Human Astrocytes-Brain | ||||
|---|---|---|---|---|
| Product Name | Human Astrocytes-Brain | |||
| Price | Get Quote | |||
| Product Code | HA | |||
| Cat.No | ABC-TC3969 | Species | Human | |
| Size/Quantity | 1 vial | Biosafety Level | 1 | |
| Shipping Info | Dry Ice | Storage | Liquid Nitrogen | |
| Description | Astrocytes are a subtype of neuroglial cells in the mammalian brain and spinal cord. With the typical star-like morphology, human astrocytes generally have sparse organelles and several processes radiating from the central cell body. A single astrocyte could be associated with a number of neuronal synapses since each process shows extensive terminal branching. HA are the most explored non-neuronal cells in the brain under neurophysiological and neurodegenerative conditions.
Astrocytes Functions Considered as full-fledged participants in brain circuitry and processing, human astrocytes provide a variety of functions at the cell level acting on the formation, maturation, and elimination of synapses, ionic homeostasis, clearance of neurotransmitters, regulation of extracellular space volume, and modulation of synaptic activity and plasticity. Astrocytes are involved in an incredible variety of processes so that a change in their characteristics will alter their contribution to neuronal functions. Some astrocytes that have vascular feet at the end of their processes take part in the forming of the blood-brain barrier (BBB). Extensive researches about the specific role of HA during neuropathological conditions have been done, however, their mechanism of action and specific role in neurodegenerative conditions could not be concluded by existing findings.
Why Choose Astrocytes from AcceGen? AcceGen Human Astrocytes are isolated from the human cerebral cortex, cryopreserved at passage one, and delivered frozen. HA from AcceGen are characterized by immunofluorescence staining for GFAP; negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi; and guaranteed to further expand for 10 population doublings under Human Astrocytes Medium provided by AcceGen. | |||
| Disease | Normal | |||
| Source Organ | Brain | |||
| Quality Control | All cells test negative for mycoplasma, bacteria, yeast, and fungi. | |||
| Recommended Medium And Supplement | ABM-TM3969 Human Astrocytes-Brain Medium Kit | |||
| Citation Guide | When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID). | |||
| Application | For research use only | |||
| Key Features | -Backed by AcceGen advanced technology | |||
| Growth Conditions | 37 ℃, 5% CO2 | |||
| Cell Type | Astrocyte | |||
| Growth Mode | Adherent | |||
| Product Type | Nervous Cells | |||
| Product Image |  | |||
Frequently Asked Questions
What are human astrocytes, and what role do they play in the nervous system?
Human astrocytes are star-shaped cells in the brain and spinal cord. They support neurons, maintain the blood-brain barrier, regulate blood flow, help repair injuries, and modulate synaptic transmission and plasticity.
How are human astrocytes typically obtained and cultured for research purposes?
Human astrocytes can be obtained from post-mortem brain samples or derived from stem cells. They are cultured in specialized media containing essential nutrients and growth factors to support their growth and functionality.
What are the main applications of human astrocytes in scientific research?
Human astrocytes are used in research on neurodevelopment, neurodegeneration, brain injury, and neuroinflammation. They help study diseases like Alzheimer’s, Parkinson’s, and multiple sclerosis, and are used to test the effects of drugs and toxins on the brain.
What are the key characteristics when culturing human astrocytes?
Key characteristics of human astrocytes in culture include their star-shaped morphology, expression of specific markers like GFAP (glial fibrillary acidic protein), and their ability to support neuronal health and function. They should exhibit healthy growth patterns, proper cell-to-cell interactions, and responsiveness to experimental conditions such as changes in media composition or the introduction of pharmacological agents.
What are the main challenges in culturing and experimenting with human astrocytes?
Challenges include keeping the cells alive and functional in vitro, replicating the complex brain environment, and preventing contamination. Variability between samples and the potential for astrocytes to become reactive under stress can also complicate experiments.
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