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Human Alveolar Macrophages | ||||
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| Product Name | Human Alveolar Macrophages | |||
| Price | Get Quote | |||
| Cat.No | ABC-H0034X | Species | Human | |
| Size/Quantity | 1 vial | Biosafety Level | 1 | |
| Shipping Info | Dry Ice | Storage | Liquid Nitrogen | |
| Description | Human Alveolar Macrophages are terminally differentiated macrophages that reside in the lung parenchyma. They are mononuclear phagocytes that guard the alveolar-blood barrier and are responsible for scavenging particles, pollutants, and invading pathogens from the airway. When encountered with viruses or large particles, alveolar macrophages (AMs) can secrete cytokines and chemokines to initiate the inflammatory process and recruit neutrophils. They also phagocytose apoptotic and necrotic cells. Altered macrophage activity has been implicated in respiratory infections and allergic lung diseases such as allergic asthma, chronic obstructive pulmonary disorder (COPD) and pulmonary alveolar proteinosis (PAP). Why choose Human Alveolar Macrophages from AcceGen? Human Alveolar Macrophages are derived from healthy human lungs with fully consented donors using AcceGen’s advanced technology. Cells are immediately cryopreserved to ensure the best viability. Each vial contains more than 5×10^5 cells in 1ml volume. Human alveolar macrophages are positive for CD68 or MAC387 by immunofluorescence staining. | |||
| Disease | Normal/Non-Small Cell Lung Cancer | |||
| Source Organ | Alveolar | |||
| Quality Control | All cell lots test negative for HIV-1, HBV, HCV, mycoplasma, yeast, fungi, and other pathogens. | |||
| Recommended Medium And Supplement | ABM-H0034X Human Alveolar Macrophages Medium Kit | |||
| Citation Guide | When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID). Laurent, Paôline et al. “Sensing of SARS-CoV-2 by pDCs and their subsequent production of IFN-I contribute to macrophage-induced cytokine storm during COVID-19.” Science immunology vol. 7,75 (2022): eadd4906. doi:10.1126/sciimmunol.add4906 | |||
| Application | For research use only Human Alveolar Macrophages provide an ideal cell source for studying the physiology and pathophysiology of alveolar macrophages. They can help understand the function and ontology of lung macrophages and may provide novel insight into therapeutic targets for lung disease. | |||
| Key Features | – Backed by AcceGen advanced technology – Cryopreserved for highest viability and plating efficiency – Quality-guaranteed for accurate results – Timely technical support for best experimental outcomes | |||
| Growth Conditions | 37 ℃, 5% CO2 | |||
| Cell Type | Macrophage | |||
| Growth Mode | Adherent | |||
| Product Type | Pulmonary Cells | |||
| Product Image |  | |||
Frequently Asked Questions
What are Human Alveolar Macrophages?
Human Alveolar Macrophages are specialized immune cells derived from the lung’s alveolar spaces. They play a critical role in the innate immune defense system by engulfing and digesting pathogens, cellular debris, and foreign particles inhaled into the lungs. These cells are crucial for maintaining pulmonary homeostasis and responding to respiratory infections.
What is the process for isolating Human Alveolar Macrophages?
Human Alveolar Macrophages are typically isolated from bronchoalveolar lavage fluid obtained during bronchoscopy procedures. The lavage fluid is centrifuged to separate the cells, which are then purified using techniques such as adhesion to plastic surfaces or gradient centrifugation to enrich the macrophage population. These cells can be cultured for research purposes, providing a model to study lung immunity and disease mechanisms.
What are the main functions of Human Alveolar Macrophages?
The main functions of Human Alveolar Macrophages include:
– Phagocytosis: Engulfing and digesting bacteria, viruses, and other foreign particles.
– Cytokine Production: Secreting signaling molecules that modulate the immune response, including pro-inflammatory and anti-inflammatory cytokines.
– Antigen Presentation: Processing and presenting antigens to T cells to initiate adaptive immune responses.
– Tissue Repair and Remodeling: Contributing to the repair of damaged lung tissue and maintaining tissue homeostasis.What are the primary applications of Human Alveolar Macrophages in research?
Human Alveolar Macrophages are used in a variety of research applications, including:
– Studying Pulmonary Diseases: Investigating the pathogenesis of diseases such as asthma, chronic obstructive pulmonary disease (COPD), tuberculosis, and lung cancer.
– Drug Testing and Development: Evaluating the efficacy and safety of new therapeutic agents targeting respiratory diseases.
– Immune Response Analysis: Understanding the immune mechanisms and responses to pathogens, allergens, and pollutants.
– Inflammation Research: Exploring the molecular pathways involved in lung inflammation and identifying potential targets for anti-inflammatory therapies.Do alveolar macrophages proliferate in vitro？
Alveolar macrophages have limited proliferative capacity in vitro. These terminally differentiated cells primarily function to defend and clear pathogens and foreign substances inhaled into the lungs. While limited proliferation can occur under specific conditions with certain growth factors or specialized culture media, they generally do not proliferate significantly. Researchers typically isolate fresh macrophages from lung tissue for experiments to ensure their functionality and activity.
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