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Human Adrenal Cortical Cells

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The adrenal cortex makes up the perimeter of the adrenal gland and plays an essential role in regulating homeostasis in the body through the secretion of corticosteroid and androgen hormones. The secreted steroids arise from three zones that form the adrenal gland, which provide the framework of the adrenal cortex. The cells in the cortex […]
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Home | Primary Cells | Human Primary Cells | Endocrine System Primary Cells | Human Adrenal Cortical Cells

Human adrenal cortical cells are derived from human adrenal cortical tissue. The fetal adrenal cortex consists of two zones, the fetal and definitive adult zones, while the adult adrenal cortex comprises three distinct zones: the outer zona glomerulosa, the central zona fasciculata, and the inner zona reticularis. These cells are organized in cord-like structures that span from the adrenal capsule to the medulla, surrounded by an extensive network of capillaries. The zona glomerulosa cells are round and smaller in size compared to the polyhedral cells of the zona fasciculata, which gradually transition into the zona reticularis. The zona reticularis contains cells similar in appearance to those in the zona fasciculata, as well as a smaller cell type. Adrenocortical cells possess the ability to secrete cytokines, active peptides, and hormones. They also interact with cytokines (TNFb, IL-1, IL-6) and peptides (VIP) released by macrophages within the adrenal cortex.

 

Why choose Human Adrenal Cortical Cells from AcceGen?

AcceGen provides human adrenal cortical cells, which are cryopreserved at passage one. These cells are characterized using 3β-HSD immunofluorescence and are confirmed negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi.

Product Code

HAdCC
Species

Human
Cat.No

ABC-TC3477
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Cortical Cell
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Adrenal
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Adrenal Cells

Citation

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Application

  • FOR RESEARCH USE ONLY

  • Human adrenal cortical cells have diverse applications in adrenal studies. They serve as a valuable model for investigating adrenal disorders like adrenal insufficiency, Cushing’s syndrome, Conn’s syndrome, and adrenocortical carcinoma. By studying these cells, researchers can unravel the molecular and biochemical mechanisms that control adrenal steroidogenesis. This knowledge can lead to better diagnostics and targeted therapies. Moreover, human adrenal cortical cells provide a platform to explore the effects of chemicals on adrenal hormone synthesis. Researchers can assess how various compounds impact hormone production, shedding light on the influence of external factors on adrenal function.

Frequently Asked Questions

  • What are Human Adrenal Cortical Cells?

    Human Adrenal Cortical Cells are specialized cells located in the adrenal cortex, the outer layer of the adrenal glands. They are responsible for producing steroid hormones such as cortisol, aldosterone, and androgens.

  • What are the main functions of Human Adrenal Cortical Cells?

    The primary functions of these cells include the production and secretion of steroid hormones, which regulate a variety of physiological processes, including metabolism, immune response, blood pressure, and stress response.

  • What applications are Human Adrenal Cortical Cells used for?

    These cells are used in endocrinology research, drug development, and studies related to adrenal gland disorders such as Addison’s disease, Cushing’s syndrome, and primary aldosteronism. They are also used to study steroidogenesis and hormonal regulation.

  • Are there any specific markers used to identify Human Adrenal Cortical Cells?

    Human Adrenal Cortical Cells can be specifically identified through immunofluorescence staining for 3β-hydroxysteroid dehydrogenase (3β-HSD), an enzyme crucial in the biosynthesis of steroid hormones. 3β-HSD is expressed predominantly in adrenal cortical cells, making it an ideal marker for distinguishing these cells from others.

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  • Adrenal (3)
  • Human (1729)
  • Normal (1578)

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