HSC-4
1
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HSC-4 is a human tongue squamous cell carcinoma (SCC) cell line that exhibits sensitivity to epidermal growth factor. Treatment with TGF-beta resulted in dose-dependent inhibition of cell growth and [3H]thymidine incorporation. Western blot analysis indicated the accumulation of a significant amount of mutant p53 protein in HSC-4 cells. Additionally, HSC-4 expresses bone morphogenetic proteins (BMPs), BMP-1 and BMP-2. Notably, this established oral cancer cell line contains a subpopulation with stem cell-like characteristics, which can be isolated using cell surface markers CD44 and SSEA-4.
Why choose HSC-4 from AcceGen?
HSC-4 from AcceGen is the ideal choice due to its high quality, viability, and serial stability. The cell line is preserved using advanced techniques, ensuring its authenticity and reliability. Additionally, AcceGen’s rigorous quality control measures further guarantee the accuracy and consistency of HSC-4, making it a trusted resource for research and experimentation.
| Product Code | HSC4 |
| Species | Human |
| Cat.No | ABC-TC0420 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial-like |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Tongue |
| Disease | Tongue Squamous Cell Cancer |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Oral Cancer Cell Lines |
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
FOR RESEARCH USE ONLY
The HSC-4 cell line finds valuable applications in the study of human oral cancer and the optimization of cancer therapy, which may necessitate novel therapeutic approaches. Notably, combined treatment with wild type p53 (wt-p53)-encoding adenovirus infection and X-irradiation has shown superior effectiveness in inhibiting cancer cell growth, in HSC4 cells with accumulated mutant p53. Moreover, HSC-4 is used to investigate and identify cancer stem-like cells that play crucial roles in chemoresistance, radioresistance, and metastasis, contributing to a deeper understanding of cancer progression and treatment resistance.
