HL-60
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HL-60 is a human leukemic cell line originated from a 36-year-old female diagnosed with acute promyelocytic leukemia. Notably, these cells possess the remarkable ability to differentiate into mature white blood cell types, including neutrophils and monocytes, when exposed to compounds such as dimethyl sulfoxide (DMSO) or retinoic acid. Characterized by a doubling time of approximately 36 to 48 hours, 
HL-60 cells exhibit heterogeneity in size, ranging from 9-25μm. They belong to the myeloblastic or promyelocytic category and display tumorigenic properties when implanted in nude mice, forming subcutaneous myeloid tumors. Gene expression analysis reveals the presence of the tumor necrosis factor (TNF) gene, specifically TNF-alpha, upon stimulation with phorbol myristic acid, as well as the myc+ gene. Notably, HL-60 cells harbor an amplified c-myc proto-oncogene, with high c-myc mRNA levels in undifferentiated cells that rapidly decline following induction of differentiation.
Why choose HL-60 from AcceGen?
HL-60 cells from AcceGen are characterized by their exceptional quality and viability. They are guaranteed to be sterile, tested negative for bacteria, fungi, and mycoplasma contamination, ensuring the utmost reliability in experiments. Identity verification is performed through STR analysis, and these cells undergo rigorous quality control to maintain their integrity and consistency.
| Product Code | HL 60; HL.60 HL60; Human Leukemia-60 |
| Species | Human |
| Cat.No | ABC-TC0389 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Myeloblastic |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Peripheral Blood |
| Disease | Acute Promyelocytic Leukemia |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Leukemia Cell Lines |
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
FOR RESEARCH USE ONLY
HL-60 cells play a crucial role in various aspects of biological science, serving as a versatile tool for a range of applications. They are instrumental in evaluating the efficacy of chemotherapy drugs and identifying vaccine targets. Additionally, these cells are invaluable in studying critical processes such as cell differentiation, phagocytosis, and calcium influx. Furthermore, HL-60 cells serve as an essential model system for investigating the cellular and molecular mechanisms involved in the proliferation and differentiation of leukemic cells. They are also utilized in the production of extracellular vesicles (EVs), making them a cornerstone in scientific research across multiple domains.
