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| Species | Human |
| Cat.No | ABC-TC0337 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Colon Cancer Cell Lines |
HCT-116 is a human colorectal carcinoma cell line that was originally isolated from the colorectal tissue of an adult male patient with colon cancer. HCT-116 exhibits epithelial-like morphology and adherent culture properties. This cell line is characterized by a specific mutation at codon 13 of the Ras proto-oncogene. The karyotype of HCT116 cells is nearly diploid. Cytokeratin expression was confirmed by immunoperoxidase staining. HCT-116 also expresses transforming growth factor beta 1 (TGF-β1) and beta 2 (TGF-β2). HCT-116 is tumorigenic in athymic nude mice.
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HCT-116 cells are extensively applied in drug screening and therapeutic research, particularly in the context of colon cancer. They carry a mutation in codon 13 of the KRAS proto-oncogene, making them suitable for gene therapy studies and viral vector transfection. These cells are also used in tumorigenicity assessments and biomedical research involving Cyclin D1 activity and siRNA uptake influenced by transferrin levels in polyethyleneimine complexes.
