HCEC-B4G12
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HCEC-B4G12 is a clonal subpopulation established in 2005 from the parental cell line HCEC-12, derived from normal corneal epithelial cells of a 91-year-old woman. These cells were transformed with the early region of the SV40 genome, which includes genes encoding large T-antigen and small t-antigen. The subclone is recognized as representing differentiated cells of the corneal endothelium. B4G12 cells are characterized by their polygonal shape, strong adherence, and formation of a strict monolayer. They have a smooth cell surface, express ZO-1 and occludin, and show limited but detectable connexin-43 expression. Additionally, B4G12 cells abundantly express collagen IV and have minimal collagen III expression, making them a valuable model for studying corneal endothelial characteristics.
Why choose HCEC-B4G12 from AcceGen?
HCEC-B4G12 cells exhibit high viability and quality, ensuring reliable research outcomes. They are maintained under sterile conditions and rigorously screened for the absence of bacterial, fungal, mycoplasma, and various viral contaminants, including EBV, HIV-1, HCV, HBV, HTLV-1/2, MLV, and SMRV. Furthermore, their identity is verified through STR analysis, guaranteeing their authenticity and consistency in scientific investigations.
| Product Code | B4G12 |
| Species | Human |
| Cat.No | ABC-TC0334 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Corneal Cell Lines |
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
FOR RESEARCH USE ONLY
HCEC-B4G12 cells, serving as an ideal model of differentiated human corneal endothelial cells (HCEC), have found crucial applications in researching the preservation of corneal function under adverse conditions. They play a pivotal role in investigating how factors like oxidative stress and inflammation impact the health and viability of corneal endothelial cells (CECs). With inflammation being a leading cause of blindness and its effects on CECs well-documented, studying the mechanisms through which these conditions affect CEC function and survival using HCEC-B4G12 cells provides essential insights for the development of strategies to mitigate vision impairment and improve ocular health.
